POSFREA J Code: J2468

Drug & Product Overview

HCPCS Descriptor Injection, palonosetron hydrochloride (posfrea), 25 micrograms

HCPCS Added Date July 1, 2024

Manufacturer Avyxa Pharma

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About POSFREA

Posfrea is a medication aligned to the HCPCS J Code: J2468 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Emetic, it is administered via the intravenous route and manufactured by Avyxa Pharma.

According to CMS Drug Use Information: This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent nausea and vomiting after surgery. Palonosetron works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Package	Manufacturer	HCPCS Units	WAC	AWP
83831-0105-01	250 MCG / 5 ML posfrea Intravenous Injection 250 MCG/5ML - 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-105-01) / 5 mL in 1 VIAL, SINGLE-DOSE	Avyxa Pharma, LLC	10	$630.68 $63.068 / unit	$756.82 $75.682 / unit

Effective 7/1/26 (WAC & AWP)

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POSFREA Pricing & Reimbursement

J2468 Private Payer Reimbursement

$60.38 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

NDC Package

HCPCS Units

Markup / Markdown

%

Common:

Estimates only. Payer reimbursement varies by contract, site of care, and sequestration.

Estimated Reimbursement

Palonosetron HCL 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2468	Avyxa Pharma	Palonosetron HCL	Injection, palonosetron hydrochloride (posfrea), 25 micrograms

POSFREA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 9.71%

Avg. Days to File 7.0days

Avg. Days to Pay 25.6days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2468 claims analytics on FocalPoint →

POSFREA CPT Administration Codes

CPT Code	Description
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

POSFREA Medically Unlikely Edits (MUE)

The most billing units of J2468 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 25 mcg.

Practitioner Office & Hospital Outpatient

10 units / day

= 250 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

POSFREA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chemotherapy-Induced Nausea and Vomiting (CINV) Postoperative Nausea and Vomiting (PONV)

Drug Class

Serotonin 3 Receptor Antagonists [MoA]Serotonin-3 Receptor Antagonist [EPC]

Frequently Asked Questions

Is there an available POSFREA billing and coding guide?

Billing and coding information for POSFREA can be found through Avyxa. Visit Here →

Are there any available POSFREA patient assistance programs?

POSFREA patient assistance information can be found through Avyxa. Visit Here →

Where can I find POSFREA prescribing information?

Prescribing information for POSFREA can be found at the link below. Visit Here →

Where can I find POSFREA side effect information?

Our team has not yet identified a source of side effects information for POSFREA. Please check back in a few weeks.

Does billing POSFREA require JZ/JW wastage modifiers?

CMS does not include POSFREA (J2468) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2468. For more information, visit the link below.

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