CPT Drug Administration Codes
For office-administered drug administration
The code list
Buy-and-Bill Drug Administration Code List
Current Procedural Terminology (CPT®) codes are five-character codes that classify the medical procedures and services performed on a patient. In buy-and-bill drug billing, the CPT code identifies how a medication was administered (infusion, injection, or chemotherapy administration) and is reported in box 24(D) of the CMS-1500 claim form. The list below is not exhaustive; it covers a selection of CPT administration codes relevant to office-administered drugs.
| CPT Code | CPT Description |
|---|---|
| 96567 | Photodynamic therapy by external application of light to destroy premalignant lesions of the skin and adjacent mucosa (eg, lip) by activation of photosensitive drug(s), per day |
| 96523 | Irrigation of implanted venous access device for drug delivery systems |
| 96522 | Refilling and maintenance of implantable pump or reservoir for drug delivery, systemic (eg, intravenous, intra-arterial) |
| 96521 | Refilling and maintenance of portable pump |
| 96450 | Chemotherapy administration, into CNS (eg, intrathecal), requiring and including spinal puncture |
| 96417 | Chemotherapy administration, intravenous infusion technique; each additional sequential infusion (different substance/drug) up to 1 hour (List separately in addition to code for primary procedure) |
| 96416 | Chemotherapy administration, IV infusion technique; initiation of prolonged chemotherapy infusion (more than 8 hours) requiring use of a portable or implantable pump |
| 96415 | Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure) |
| 96413 | Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug |
| 96411 | Chemotherapy administration; intravenous, push technique, each additional substance/drug (List separately in addition to code for primary procedure) |
| 96409 | Chemotherapy administration; intravenous, push technique, single or initial substance/drug |
| 96405 | Chemotherapy administration; intralesional, up to and including 7 lesions |
| 96402 | Chemotherapy administration, subcutaneous or intramuscular; hormonal anti-neoplastic |
| 96401 | Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic |
| 96377 | Application of on-body injector (includes cannula insertion) for timed subcutaneous injection |
| 96375 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug (List separately in addition to code for primary procedure) |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96371 | Subcutaneous infusion for therapy or prophylaxis (specify substance or drug); additional pump set-up with establishment of new subcutaneous infusion site(s) (List separately in addition to code for primary procedure) |
| 96370 | Subcutaneous infusion for therapy or prophylaxis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
| 96369 | Subcutaneous infusion for therapy or prophylaxis (specify substance or drug); initial, up to 1 hour, including pump set-up and establishment of subcutaneous infusion site(s) |
| 96368 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); concurrent infusion (List separately in addition to code for primary procedure) |
| 96367 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); additional sequential infusion of a new drug/substance, up to 1 hour (List separately in addition to code for primary procedure) |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96361 | Intravenous infusion, hydration; each additional hour (List separately in addition to code for primary procedure) |
| 96360 | Intravenous infusion, hydration; initial, 31 minutes to 1 hour |
| 94070 | Bronchospasm provocation evaluation, multiple spirometric determinations as in 94010, with administered agents (e.g., antigen[s], cold air, methacholine) |
| 90935 | Hemodialysis procedure with single evaluation by a physician or other qualified healthcare professional |
| 90472 | Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); each additional vaccine (single or combination vaccine/toxoid) (List separately in addition to code for primary procedure) |
| 90471 | Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections), one vaccine (single or combination vaccine/toxoid) |
| 90461 | Immunization administration through 18 years of age via any route of administration, with counseling by physician or other qualified health care professional; each additional vaccine or toxoid component administered (List separately in addition to code for primary procedure) |
| 90460 | Immunization administration via any route, first vaccine/toxoid component |
| 81235 | EGFR (epidermal growth factor receptor) (eg, non-small cell lung cancer) gene analysis, common variants (eg, exon 19 LREA deletion, L858R, T790M, G719A, G719S, L861Q) |
| 80076 | Hepatic function panel test in which the blood levels of protein, albumin, alkaline phosphatase, bilirubin, and liver enzymes are measured |
| 79101 | Radiopharmaceutical therapy, by intravenous administration |
| 78812 | Positron emission tomography (PET) imaging; skull base to mid-thigh |
| 78811 | Positron emission tomography (PET) imaging; limited area (eg, chest, head/neck) |
| 78607 | Brain imaging, tomographic (SPECT) |
| 78227 | Hepatobiliary system imaging, including gallbladder when present; with pharmacologic intervention, including quantitative measurement(s) when performed |
| 68841 | Insertion of drug-eluting implant, including punctal dilation when performed, into lacrimal canaliculus, each |
| 67516 | Suprachoroidal injection of a pharmacologic agent; does not include supply of medication |
| 67221 | Destruction of localized lesion of choroid (eg, choroidal neovascularization); photodynamic therapy (includes intravenous infusion) |
| 67036 | Vitrectomy, mechanical, pars plana approach |
| 67028 | Intravitreal injection of a pharmacologic agent (separate procedure) |
| 67027 | Implantation of intravitreal drug delivery system, includes concomitant removal of vitreous |
| 66984 | Extracapsular cataract removal with insertion of intraocular lens prosthesis (1-stage procedure), manual or mechanical technique (eg, irrigation and aspiration or phacoemulsification); without endoscopic cyclophotocoagulation |
| 66030 | Injection, anterior chamber of eye (separate procedure); medication |
| 64620 | Destruction by neurolytic agent, intercostal nerve |
| 64616 | Chemodenervation of muscle(s); neck muscle(s), excluding muscles of larynx, unilateral (eg, for cervical dystonia, spasmodic torticollis) |
| 64455 | Injection(s), anesthetic agent(s) and/or steroid; plantar common digital nerve(s) (eg, Morton's neuroma) |
| 62369 | Electronic analysis of programmable, implanted pump for intrathecal or epidural drug infusion (includes evaluation of reservoir status, alarm status, drug prescription status); with reprogramming and refill |
| 62322 | Injection(s), of diagnostic or therapeutic substance(s) (eg, anesthetic, antispasmodic, opioid, steroid, other solution), not including neurolytic substances, including needle or catheter placement, interlaminar epidural or subarachnoid, lumbar or sacral (caudal); without imaging guidance |
| 61210 | Burr hole(s); for implanting ventricular catheter, reservoir, EEG electrode(s), pressure recording device, or other cerebral monitoring device (separate procedure) |
| 58300 | Insertion, intrauterine device |
| 51720 | Bladder instillation of anticarcinogenic agent, including retention time |
| 38241 | Hematopoietic progenitor cell (HPC); autologous transplantation |
| 38225 | Chimeric antigen receptor T cell (CAR T) therapy; harvesting of blood-derived T lymphocytes for development of genetically modified autologous CAR T cells, per day |
| 37195 | Thrombolysis, cerebral, by intravenous infusion |
| 27412 | Autologous chondrocyte implantation, knee |
| 20610 | Arthrocentesis, aspiration and/or injection, major joint or bursa (eg, shoulder, hip, knee, subacromial bursa); without ultrasound guidance |
| 11981 | Insertion, drug-delivery implant (ie, bioresorbable, biodegradable, non-biodegradable) |
| 11980 | Subcutaneous hormone pellet implantation (implantation of estradiol and/or testosterone pellets beneath the skin) |
AMA/CPT Copyright Notice — CPT codes, descriptions, and other data only are copyright 2025 American Medical Association. All Rights Reserved.
FAQ
Frequently asked questions
What is a CPT drug administration code?
A CPT drug administration code is a five-character code that describes how a medication was given, such as by IV infusion, injection, or chemotherapy administration. It identifies the procedure of administering the drug, not the drug itself.
Where does the CPT administration code go on a claim?
On the CMS-1500 professional claim, the CPT administration code is entered in box 24(D) for each service line, alongside any applicable modifiers. The drug being administered is reported separately with its HCPCS (J/Q/C) code and NDC.
What is the difference between a CPT administration code and a HCPCS J code?
The CPT administration code describes the procedure of giving the drug (the infusion or injection), while the HCPCS code (such as a J code) identifies the drug itself and the units supplied. A typical buy-and-bill claim line carries both: one for the administration and one for the product.
How often do CPT codes change?
The American Medical Association maintains the CPT code set and updates it annually, with most changes effective January 1. Codes can be added, revised, or deleted each cycle, so administration codes should be verified against the current CPT manual.
