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Updated July 1st, 2026

Granisetron HCl Q Code: Q0166

Granisetron hydrochloride, 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 24 hour dosage regimen

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Q4 2026 Medicare Payment Limit for Q0166, effective October 1, 2026: $0.774 per HCPCS billing unit. CMS publishes none for Q3 2026. From CMS's final file.

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Granisetron hydrochloride, 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 24 hour dosage regimen
HCPCS Added Date April 1, 1998
Manufacturer Breckenridge
Route of Administration Oral
Generic Status Single-Source; Branded
Dosage Form Tablet

About Granisetron HCl

Granisetron HCl is a medication aligned to the HCPCS Q Code: Q0166 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Emetic, it is administered via the oral route and manufactured by Breckenridge.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
51991-0735-20 Granisetron Hydrochloride Breckenridge Pharmaceutical, Inc. 20 1 MG
51991-0735-32 Granisetron Hydrochloride Breckenridge Pharmaceutical, Inc. 2 1 MG
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Granisetron HCl Pricing & Reimbursement

Q0166 Private Payer Reimbursement
$2.92 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Granisetron HCl Medically Unlikely Edits (MUE)

The most billing units of Q0166 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
0 units / day
Not payable in this setting
Hospital Outpatient
2 units / day
= 2 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.
Not on the CMS JW / JZ list

CMS does not include Granisetron HCl (Q0166) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q0166. Wastage billing guide →

Granisetron HCl Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Nausea and vomiting associated with emetogenic cancer therapy Nausea and vomiting associated with radiation
Drug Class
Serotonin 3 Receptor Antagonists [MoA]Serotonin-3 Receptor Antagonist [EPC]

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Frequently Asked Questions

Is there an available Granisetron HCl billing and coding guide?
We have not yet identified a manufacturer source of Granisetron HCl billing and coding information.
Are there any available Granisetron HCl patient assistance programs?
Our team did not identify a source for Granisetron HCl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Granisetron HCl prescribing information?
Granisetron HCl prescribing information can be found at the link below. Visit Here →
Where can I find Granisetron HCl side effect information?
Information regarding Granisetron HCl's side effects can be found at MedlinePlus. Visit Here →
Does billing Granisetron HCl require JZ/JW wastage modifiers?
This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers.

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