Home › Drug Codes › Q Codes › Q0162 · Ondansetron
Updated July 1st, 2026

Ondansetron Q Code: Q0162

Ondansetron 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen

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Q4 2026 Medicare Payment Limit for Q0162, effective October 1, 2026: $0.016 per HCPCS billing unit, unchanged from Q3 2026. From CMS's final file.

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Medicare Payment Limit ?
$0.016
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
126
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Drug & Product Overview

HCPCS Descriptor Ondansetron 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
HCPCS Added Date January 1, 2012
Manufacturer Multiple Manufacturers
Route of Administration Oral
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Not Available | Solution | Tablet | Tablet, Film Coated | Tablet, Orally Disintegrating

About Ondansetron

Ondansetron is a medication aligned to the HCPCS Q Code: Q0162 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Emetic drug administered via the oral route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 126 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00904-6551-61 Ondansetron Major Pharmaceuticals 400 4 MG
16714-0159-01 Ondansetron NorthStar Rx LLC 120 4 MG
43063-0792-06 Ondansetron Hydrochloride PD-Rx Pharmaceuticals, Inc. 48 8 MG
50090-1128-01 Ondansetron A-S Medication Solutions 240 8 MG
50268-0621-15 Ondansetron Hydrochloride AvPAK 200 4 MG
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Ondansetron Pricing & Reimbursement

Q0162 Private Payer Reimbursement
$0.02 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Ondansetron CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Login for More Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) Login for More
Not on the CMS JW / JZ list

CMS does not include Ondansetron (Q0162) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q0162. Wastage billing guide →

Ondansetron Medically Unlikely Edits (MUE)

The most billing units of Q0162 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
0 units / day
Not payable in this setting
Hospital Outpatient
24 units / day
= 24 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Ondansetron Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Highly Emetogenic Cancer Chemotherapy Moderately Emetogenic Cancer Chemotherapy Nausea and Vomiting associated with Radiotherapy Nausea and vomiting associated with highly emetogenic cancer chemotherapy Nausea and vomiting associated with moderately emetogenic cancer chemotherapy Nausea and vomiting associated with radiotherapy Nausea and vomiting associated with radiotherapy — daily fractions to the abdomen Nausea and vomiting associated with radiotherapy — single high-dose fraction to the abdomen Nausea and vomiting associated with radiotherapy — total body irradiation Postoperative Nausea and Vomiting Postoperative Nausea and/or Vomiting Postoperative nausea and vomiting Postoperative nausea and/or vomiting Radiotherapy — Daily Fractions to the Abdomen Radiotherapy — Single High-Dose Fraction to the Abdomen Radiotherapy — Total Body Irradiation Radiotherapy-associated nausea and vomiting Radiotherapy-induced Nausea and Vomiting Radiotherapy-induced nausea and vomiting
Drug Class
Serotonin 3 Receptor Antagonists [MoA]Serotonin-3 Receptor Antagonist [EPC]

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Frequently Asked Questions

Is there an available Ondansetron billing and coding guide?
We have not yet identified a manufacturer source of Ondansetron billing and coding information.
Are there any available Ondansetron patient assistance programs?
Our team did not identify a source for Ondansetron patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Ondansetron prescribing information?
Our team is still working to identify a prescribing information source for Ondansetron
Where can I find Ondansetron side effect information?
Our team has not yet identified a source of side effects information for Ondansetron. Please check back in a few weeks.
Does billing Ondansetron require JZ/JW wastage modifiers?
CMS does not include Ondansetron (Q0162) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q0162. For more information, visit the link below.

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