APREPITANT J Code: J8501

Drug & Product Overview

HCPCS Descriptor Aprepitant, oral, 5 mg

HCPCS Added Date January 1, 2005

Manufacturer Multiple Manufacturers

Route of Administration Oral

Generic Status Multi-Source; Generic

Dosage Form Capsule | Kit | Powder, For Suspension

About APREPITANT

Aprepitant is a medication aligned to the HCPCS J Code: J8501 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Emetic, it is administered via the oral route and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 33 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00006-0461-02	Emend	Merck Sharp & Dohme LLC	32	80 MG
00781-2321-06	Aprepitant	Sandoz Inc	8	40 MG
13668-0591-81	Aprepitant	Torrent Pharmaceuticals Limited	8	40 MG
68001-0666-01	Aprepitant	BluePoint Laboratories	8	40 MG
68462-0112-33	Aprepitant	Glenmark Pharmaceuticals Inc., USA	57	Kit
•••••-••••-•• Log in to view	APREPITANT
	APREPITANT
	APREPITANT

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APREPITANT Pricing & Reimbursement

J8501 Private Payer Reimbursement

$2.68 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

APREPITANT CPT Administration Codes

CPT Code	Description
96375	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug.
96367	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); additional sequential infusion of a new drug/substance, up to 1 hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Aprepitant (J8501) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J8501. Wastage billing guide →

APREPITANT Medically Unlikely Edits (MUE)

The most billing units of J8501 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

0 units / day

Not payable in this setting

Hospital Outpatient

57 units / day

= 285 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

APREPITANT Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chemotherapy Induced Nausea and Vomiting Chemotherapy Induced Nausea and Vomiting (CINV) Postoperative Nausea and Vomiting Postoperative Nausea and Vomiting (PONV) nausea and vomiting associated with highly emetogenic cancer chemotherapy (HEC) nausea and vomiting associated with moderately emetogenic cancer chemotherapy (MEC)

Drug Class

Cytochrome P450 2C9 Inducers [MoA]Cytochrome P450 3A4 Inducers [MoA]Cytochrome P450 3A4 Inhibitors [MoA]Neurokinin 1 Antagonists [MoA]Substance P/Neurokinin-1 Receptor Antagonist [EPC]

Frequently Asked Questions

Is there an available Aprepitant billing and coding guide?

We have not yet identified a manufacturer source of Aprepitant billing and coding information.

Are there any available Aprepitant patient assistance programs?

Our team did not identify a source for Aprepitant patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Aprepitant prescribing information?

APREPITANT prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Aprepitant side effect information?

Our team has not yet identified a source of side effects information for APREPITANT. Please check back in a few weeks.

Does billing APREPITANT require JZ/JW wastage modifiers?

CMS does not include APREPITANT (J8501) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J8501. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.