Home › Drug Codes › J Codes › J2469 · Palonosetron
Updated July 1st, 2026

Palonosetron J Code: J2469

Injection, palonosetron hcl, 25 mcg

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Q4 2026 Medicare Payment Limit for J2469, effective October 1, 2026: $0.469 per HCPCS billing unit, down 18.3% from $0.574. From CMS's final file.

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Medicare Payment Limit ?
$0.574
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
23
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Drug & Product Overview

HCPCS Descriptor Injection, palonosetron hcl, 25 mcg
HCPCS Added Date January 1, 2005
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection | Injection, Solution | Not Available

About Palonosetron

Palonosetron is a medication aligned to the HCPCS J Code: J2469 for billing, pricing, and reimbursement purposes in the United States. This Anti-Emetic medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent nausea and vomiting after surgery. Palonosetron works by blocking one of the body's natural substances (serotonin) that causes vomiting.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 23 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00409-2504-10 Palonosetron Pfizer Inc 10 0.25 MG / 5 ML
00703-4094-01 Palonosetron Hydrochloride Teva Parenteral Medicines, Inc. 10 250 MCG / 5 ML
00781-3312-75 Palonosetron Hydrochloride Sandoz Inc 10 250 MCG / 5 ML
00781-3415-75 Palonosetron Sandoz Inc. 10 250 MCG / 5 ML
16714-0834-01 Palonosetron NorthStar Rx LLC 10 250 MCG / 5 ML
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Palonosetron
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Palonosetron Pricing & Reimbursement

J2469 Private Payer Reimbursement
$0.52 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Palonosetron Hydrochloride 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2469 Generic Code (Multiple Manufacturers) Palonosetron Hydrochloride Injection, palonosetron hcl, 25 mcg

Palonosetron Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 10.35%
Avg. Days to File 10.0days
Avg. Days to Pay 24.4days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2469 claims analytics on FocalPoint →
OnPoint Oncology

Palonosetron CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Palonosetron (J2469) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2469. Wastage billing guide →

Palonosetron Medically Unlikely Edits (MUE)

The most billing units of J2469 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 25 mcg.

Practitioner Office & Hospital Outpatient
60 units / day
= 1,500 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

Palonosetron Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chemotherapy-Induced Nausea and Vomiting Chemotherapy-Induced Nausea and Vomiting (MEC and HEC) Chemotherapy-Induced Nausea and Vomiting (emetogenic, including HEC) Postoperative Nausea and Vomiting Postoperative Nausea and Vomiting (PONV) chemotherapy-induced nausea and vomiting postoperative nausea and vomiting
Drug Class
Serotonin 3 Receptor Antagonists [MoA]Serotonin-3 Receptor Antagonist [EPC]

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Frequently Asked Questions

Is there an available Palonosetron billing and coding guide?
We have not yet identified a manufacturer source of Palonosetron billing and coding information.
Are there any available Palonosetron patient assistance programs?
Our team did not identify a source for Palonosetron patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Palonosetron prescribing information?
Palonosetron prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Palonosetron side effect information?
Our team has not yet identified a source of side effects information for Palonosetron. Please check back in a few weeks.
Does billing Palonosetron require JZ/JW wastage modifiers?
CMS does not include Palonosetron (J2469) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2469. For more information, visit the link below.

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