ONDANSETRON HCL J Code: J2405
Injection, ondansetron hydrochloride, per 1 mg
Q4 2026 Medicare Payment Limit for J2405, effective October 1, 2026: $0.084 per HCPCS billing unit, down 4.5% from $0.088. From CMS's final file.
Drug & Product Overview
About ONDANSETRON HCL
Ondansetron HCL is a medication aligned to the HCPCS J Code: J2405 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Emetic, it is administered via the intramuscular or intravenous routes and manufactured by multiple companies.
According to CMS Drug Use Information: This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer chemotherapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 39 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00409-0009-25 | Ondansetron | Hospira, Inc. | 100 | 4 MG / 2 ML |
| 00641-6078-25 | Ondansetron | Hikma Pharmaceuticals USA Inc. | 100 | 4 MG / 2 ML |
| 16729-0298-05 | ondansetron | Accord Healthcare, Inc. | 40 | 40 MG / 20 ML |
| 23155-0547-42 | Ondansetron | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 100 | 4 MG / 2 ML |
| 25021-0777-02 | ondansetron | Sagent Pharmaceuticals | 100 | 4 MG / 2 ML |
| •••••-••••-•• Log in to view | ONDANSETRON HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | ONDANSETRON HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | ONDANSETRON HCL | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
ONDANSETRON HCL Pricing & Reimbursement
National median reimbursement across major commercial payers.
Create an account on PayerPrice for more information →
Historical Graphing and Billing Calculator
Log in to calculate billing and reimbursement with live ASP, WAC & AWP pricing.
Login to use the calculator →ONDANSETRON HCL CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
CMS does not include Ondansetron HCL (J2405) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2405. Wastage billing guide →
ONDANSETRON HCL Medically Unlikely Edits (MUE)
The most billing units of J2405 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
ONDANSETRON HCL Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
Login for BuyandBill.com Analytics
Unlock deeper insights with BuyandBill’s Comparative Report!
- Compare ASP, WAC, and AWP across drugs.
- Visualize Drug Price Movement Over Time
- Tailor reports to drug class, manufacturer, or HCPCS Code.
- Compare Biosimilar and 505(b)(2) products.
Frequently Asked Questions
Is there an available Ondansetron Hcl billing and coding guide?
Are there any available Ondansetron Hcl patient assistance programs?
Where can I find Ondansetron Hcl prescribing information?
Where can I find Ondansetron Hcl side effect information?
Does billing ONDANSETRON HCL require JZ/JW wastage modifiers?
About BuyandBill.com:
The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.
Related Drug Codes
Explore billing, coding, and pricing for drugs related to ONDANSETRON HCL.
