Nafcillin sodium J Code: J2290

Drug & Product Overview

HCPCS Descriptor Injection, nafcillin sodium, 20 mg

HCPCS Added Date January 1, 2025

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Form Injection, Powder, For Solution | Injection, Powder, Lyophilized, For Solution | Not Available | Powder, For Solution

About Nafcillin sodium

Nafcillin Sodium is a medication aligned to the HCPCS J Code: J2290 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat a wide variety of bacterial infections. This medication is known as a penicillin-type antibiotic. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 31 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
23155-0906-41	Nafcillin	Heritage Pharmaceuticals Inc. d/b/a/ Avet Pharmaceuticals Inc.	500	1000 MG / 4 ML
25021-0139-10	Nafcillin Sodium	Sagent Pharmaceuticals	500	Nafcillin Sodium Injec tion Solution Re… Login for More
44567-0221-10	Nafcillin	WG Critical Care, LLC	500	Nafcillin Intramuscula r Injection 1 G/… Login for More
55150-0122-15	Nafcillin	Eugia US LLC	500	1000 MG / 4 ML
63323-0327-10	Nafcillin	Fresenius Kabi USA, LLC	500	1000 MG / 4 ML
•••••-••••-•• Log in to view	Nafcillin sodium
	Nafcillin sodium
	Nafcillin sodium

Login to view 26 more NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

Nafcillin sodium Pricing & Reimbursement

J2290 Private Payer Reimbursement

$0.06 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Nafcillin Sodium 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2290	Generic Code (Multiple Manufacturers)	Nafcillin Sodium	Injection, nafcillin sodium, 20 mg
J2291	Baxter Healthcare	Nafcillin Sodium	Injection, nafcillin sodium (baxter), 20 mg

Nafcillin sodium CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

Nafcillin sodium Medically Unlikely Edits (MUE)

The most billing units of J2290 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 20 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 6,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Nafcillin sodium Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Infections caused by penicillinase-producing staphylococci infections caused by penicillinase-producing staphylococci

Drug Class

Penicillin-class Antibacterial [EPC]Penicillins [CS]

Frequently Asked Questions

Is there an available Nafcillin sodium billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Nafcillin sodium

What are the available Nafcillin sodium patient assistance programs?

Our team has not identified a source of patient assistance information for Nafcillin sodium

Where can I find Nafcillin sodium prescribing information?

Nafcillin sodium prescribing information can be found at the link below. Visit Here →

Where can I find Nafcillin sodium side effect information?

Nafcillin sodium side effect information can be found through MedlinePlus at the link below.

Does billing Nafcillin sodium require JZ/JW wastage modifiers?

CMS does not include Nafcillin sodium (J2290) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2290. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.