Home › Drug Codes › J Codes › J2540 · PENICILLIN G POTASSIUM
Updated July 1st, 2026

PENICILLIN G POTASSIUM J Code: J2540

Injection, penicillin g potassium, up to 600,000 units

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Q4 2026 Medicare Payment Limit for J2540, effective October 1, 2026: $0.781 per HCPCS billing unit, up 22.6% from $0.637. From CMS's final file.

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Medicare Payment Limit ?
$0.637
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
21
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Drug & Product Overview

HCPCS Descriptor Injection, penicillin g potassium, up to 600,000 units
HCPCS Added Date January 1, 1982
Manufacturer Multiple Manufacturers
Route of Administration Intramuscular, Intrapleural, Intrathecal, Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection, Powder, For Solution | Injection, Solution | Not Available | Powder, For Solution

About PENICILLIN G POTASSIUM

Penicillin G Potassium is a medication aligned to the HCPCS J Code: J2540 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intramuscular, intrapleural, intrathecal, or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat a wide variety of bacterial infections. It is also used to prevent infection of the heart (bacterial endocarditis) in patients with certain heart diseases who are having surgery. This medication is known as a natural penicillin antibiotic. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 21 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00049-0420-10 Pfizerpen Roerig 84 Pfizerpen Intramuscula r Powder 5000000… Login for More
00338-1023-41 Penicillin G Potassium Baxter Healthcare Corporation 4 Penicillin G Potassium Intravenous Inj… Login for More
00781-6135-95 Penicillin G Potassium Sandoz Inc 84 Penicillin G Potassium Intramuscular I… Login for More
25021-0153-20 Penicillin G Potassium Sagent Pharmaceuticals 84 Penicillin G Potassium Intramuscular I… Login for More
44567-0311-10 Penicillin G Potassium WG Critical Care, LLC 84 Penicillin G Potassium Intramuscular I… Login for More
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PENICILLIN G POTASSIUM
PENICILLIN G POTASSIUM
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PENICILLIN G POTASSIUM Pricing & Reimbursement

J2540 Private Payer Reimbursement
$0.93 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

PENICILLIN G POTASSIUM CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More
Not on the CMS JW / JZ list

CMS does not include Penicillin G Potassium (J2540) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2540. Wastage billing guide →

PENICILLIN G POTASSIUM Medically Unlikely Edits (MUE)

The most billing units of J2540 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 600000 units.

Practitioner Office & Hospital Outpatient
75 units / day
= 45,000,000 units per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

units Enter a dose to see how many billing units it is and whether it is under the limit.

PENICILLIN G POTASSIUM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Actinomycosis (cervico-facial disease) Actinomycosis (cervicofacial disease) Actinomycosis (thoracic and abdominal disease) Actinomycosis - cervicofacial disease Actinomycosis - thoracic and abdominal disease Actinomycosis — cervicofacial disease Actinomycosis — thoracic and abdominal disease Actinomycosis, cervicofacial disease Actinomycosis, thoracic and abdominal disease Anthrax Botulism Botulism (adjunctive therapy to antitoxin) Botulism (adjunctive therapy to antitoxin), gas gangrene, tetanus (adjunctive therapy to human tetanus immune globulin) Botulism, gas gangrene, and tetanus (Clostridial infections) Clostridial infections (botulism, gas gangrene, tetanus) Diphtheria Diphtheria (adjunctive therapy to antitoxin and for prevention of the carrier state) Diphtheria (adjunctive therapy to antitoxin and for the prevention of the carrier state) Diphtheria (adjunctive therapy to antitoxin and prevention of carrier state) Disseminated Gonococcal Infections (penicillin-susceptible strains) - arthritis Disseminated Gonococcal Infections (penicillin-susceptible strains) - arthritis, meningitis, endocarditis Disseminated Gonococcal Infections (penicillin-susceptible strains) - endocarditis Disseminated Gonococcal Infections (penicillin-susceptible strains) - meningitis Disseminated Gonococcal Infections (penicillin-susceptible strains), arthritis Disseminated Gonococcal Infections (penicillin-susceptible strains), arthritis, meningitis, endocarditis Disseminated Gonococcal Infections (penicillin-susceptible strains), endocarditis Disseminated Gonococcal Infections (penicillin-susceptible strains), meningitis Disseminated Gonococcal Infections — arthritis Disseminated Gonococcal Infections — arthritis, meningitis, endocarditis Disseminated Gonococcal Infections — endocarditis Disseminated Gonococcal Infections — meningitis Disseminated gonococcal infections Disseminated gonococcal infections (arthritis) Disseminated gonococcal infections (arthritis, meningitis, endocarditis) Disseminated gonococcal infections (endocarditis) Disseminated gonococcal infections (meningitis) Disseminated gonococcal infections (penicillin-susceptible strains) — arthritis Disseminated gonococcal infections (penicillin-susceptible strains) — arthritis, meningitis, endocarditis Disseminated gonococcal infections (penicillin-susceptible strains) — endocarditis Disseminated gonococcal infections (penicillin-susceptible strains) — meningitis Disseminated gonococcal infections (penicillin-susceptible strains), arthritis Disseminated gonococcal infections (penicillin-susceptible strains), arthritis/meningitis/endocarditis Disseminated gonococcal infections (penicillin-susceptible strains), endocarditis Disseminated gonococcal infections (penicillin-susceptible strains), meningitis Disseminated gonococcal infections — arthritis Disseminated gonococcal infections — arthritis, meningitis, endocarditis Disseminated gonococcal infections — endocarditis Disseminated gonococcal infections — meningitis Erysipelothrix endocarditis Fusospirochetosis (severe infections of the oropharynx [Vincent's], lower respiratory tract and genital area) Fusospirochetosis (severe infections of the oropharynx, lower respiratory tract and genital area) Gas gangrene Gas gangrene (debridement and/or surgery as indicated) Haverhill fever Haverhill fever and Rat-bite fever Haverhill fever and rat-bite fever Haverhill fever; Rat-bite fever Listeria endocarditis Listeria infections - endocarditis Listeria infections - meningitis Listeria infections — endocarditis Listeria infections — meningitis Listeria infections, endocarditis Listeria infections, meningitis Listeria meningitis Meningitis caused by susceptible strains of pneumococcus and meningococcus Meningococcal meningitis and/or septicemia Pasteurella infections (including bacteremia and meningitis) Pasteurella infections including bacteremia and meningitis Rat bite fever Rat-bite fever and Haverhill fever (with endocarditis caused by S. moniliformis) Rat-bite fever; Haverhill fever (with endocarditis caused by S. moniliformis) Septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis due to susceptible strains of staphylococci Septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis due to susceptible strains of streptococci (including S. pneumoniae) Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis due to susceptible strains of staphylococci Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis due to susceptible strains of streptococci (including S. pneumoniae) Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis due to susceptible strains of streptococci and staphylococci Serious infections (pneumonia and endocarditis) due to susceptible strains of streptococci (including S. pneumoniae) and meningococcus Serious infections (pneumonia, endocarditis) due to susceptible strains of streptococci (including S. pneumoniae) and meningococcus Serious infections (pneumonia, endocarditis) due to susceptible strains of streptococci and meningococcus Serious infections due to susceptible strains of staphylococci - septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis Serious infections due to susceptible strains of staphylococci — septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis Serious infections due to susceptible strains of streptococci (including S. pneumoniae) - septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis Serious infections due to susceptible strains of streptococci (including S. pneumoniae) and meningococcus — pneumonia and endocarditis Serious infections due to susceptible strains of streptococci (including S. pneumoniae) — septicemia, empyema, pneumonia, pericarditis, endocarditis and meningitis Syphilis (congenital and neurosyphilis) after the newborn period Syphilis (neurosyphilis) Tetanus Tetanus (adjunctive therapy to human tetanus immune globulin)
Drug Class
Penicillin-class Antibacterial [EPC]Penicillins [CS]

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Frequently Asked Questions

Is there an available Penicillin G Potassium billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for PENICILLIN G POTASSIUM.
Are there any available Penicillin G Potassium patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for PENICILLIN G POTASSIUM.
Where can I find Penicillin G Potassium prescribing information?
Our team is still working to identify a prescribing information source for PENICILLIN G POTASSIUM
Where can I find Penicillin G Potassium side effect information?
Our team has not yet identified a source of side effects information for PENICILLIN G POTASSIUM. Please check back in a few weeks.
Does billing PENICILLIN G POTASSIUM require JZ/JW wastage modifiers?
CMS does not include PENICILLIN G POTASSIUM (J2540) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2540. For more information, visit the link below.

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