Ampicillin J Code: J0290
Injection, ampicillin sodium, 500 mg
Q4 2026 Medicare Payment Limit for J0290, effective October 1, 2026: $0.619 per HCPCS billing unit, up 0.8% from $0.614. From CMS's final file.
Drug & Product Overview
About Ampicillin
Ampicillin is a medication aligned to the HCPCS J Code: J0290 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intramuscular or intravenous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Ampicillin is used to treat a wide variety of bacterial infections. It is a penicillin-type antibiotic. It works by stopping the growth of bacteria.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 101 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00781-3400-95 | Ampicillin Sodium | Sandoz Inc. | 3 | 125 MG |
| 00781-3402-95 | Ampicillin | Sandoz Inc | 5 | 250 MG |
| 23155-0915-41 | Ampicillin | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 10 | 500 MG |
| 25021-0134-10 | Ampicillin Sodium | Sagent Pharmaceuticals | 5 | 250 MG |
| 44567-0100-10 | Ampicillin | WG Critical Care, LLC | 5 | 250 MG |
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Ampicillin Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Ampicillin CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
| 96372 Login for More | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More |
CMS does not include Ampicillin (J0290) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0290. Wastage billing guide →
Ampicillin Medically Unlikely Edits (MUE)
The most billing units of J0290 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 500 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
Ampicillin Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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