AZTREONAM J Code: J0457

Drug & Product Overview

HCPCS Descriptor Injection, aztreonam, 100 mg

HCPCS Added Date July 1, 2023

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Powder, For Solution | Injection, Powder, Lyophilized, For Solution

About AZTREONAM

Aztreonam is a medication aligned to the HCPCS J Code: J0457 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Aztreonam is used to treat a wide variety of bacterial infections. This medication is an antibiotic that works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 15 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00003-2560-16	Azactam	E.R. Squibb & Sons, L.L.C.	100	Azactam Intramuscular Injection 1 G/1 … Login for More
00003-2570-16	Azactam	E.R. Squibb & Sons, L.L.C.	200	Azactam Intramuscular Injection 2 G/1 … Login for More
00409-0829-01	Aztreonam	Hospira, Inc.	100	Aztreonam Intramuscula r Injection 1 G/… Login for More
50090-7494-00	Azactam	A-S Medication Solutions	100	Azactam Intramuscular Injection 1 G/1 … Login for More
63323-0401-20	Aztreonam	Fresenius Kabi USA, LLC	100	Aztreonam Intramuscula r Injection 1 G/… Login for More
•••••-••••-•• Log in to view	AZTREONAM
	AZTREONAM
	AZTREONAM

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AZTREONAM Pricing & Reimbursement

J0457 Private Payer Reimbursement

$2.26 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Aztreonam 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J0457	Generic Code (Multiple Manufacturers)	Aztreonam	Injection, aztreonam, 100 mg
J0458	AbbVie	Aztreonam	Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg)

AZTREONAM CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Aztreonam (J0457) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

AZTREONAM Medically Unlikely Edits (MUE)

The most billing units of J0457 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 100 mg.

Practitioner Office & Hospital Outpatient

80 units / day

= 8,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

AZTREONAM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Gynecologic Infections Intra-abdominal Infections Lower Respiratory Tract Infections Moderately Severe Systemic Infections Septicemia Severe Systemic or Life-Threatening Infections Skin and Skin-Structure Infections Urinary Tract Infections

Drug Class

Monobactam Antibacterial [EPC]Monobactams [CS]

Frequently Asked Questions

Is there an available Aztreonam billing and coding guide?

We have not yet identified a manufacturer source of Aztreonam billing and coding information.

Are there any available Aztreonam patient assistance programs?

Our team did not identify a source for Aztreonam patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Aztreonam prescribing information?

Our team is still working to identify a prescribing information source for AZTREONAM

Where can I find Aztreonam side effect information?

Our team has not yet identified a source of side effects information for AZTREONAM. Please check back in a few weeks.

Does billing AZTREONAM require JZ/JW wastage modifiers?

CMS has identified AZTREONAM(J0457) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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