PIPERACILLIN AND TAZOBACTAM J Code: J2543
Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
Q4 2026 Medicare Payment Limit for J2543, effective October 1, 2026: $1.183 per HCPCS billing unit, down 2.9% from $1.218. From CMS's final file.
Drug & Product Overview
About PIPERACILLIN AND TAZOBACTAM
Piperacillin AND Tazobactam is a medication aligned to the HCPCS J Code: J2543 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous or parenteral routes and manufactured by multiple companies.
According to CMS Drug Use Information: Piperacillin/tazobactam is used to treat a wide variety of bacterial infections. It is a penicillin antibiotic. It works by stopping the growth of bacteria.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 114 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00264-3446-11 | Piperacillin and Tazobactam and Sodium Chloride | B. Braun Medical Inc. | 48 | Piperacillin and Tazob actam and Sodium… Login for More |
| 00338-9632-24 | Zosyn | Baxter Healthcare Corporation | 48 | Zosyn Intravenous Inje ction 2 GM/50ML … Login for More |
| 00409-2999-14 | Piperacillin and Tazobactam | Hospira, Inc | 12 | Piperacillin and Tazob actam Intravenou… Login for More |
| 00409-3374-02 | Piperacillin Sodium-Tazobactam Sodium | Pfizer Inc | 20 | Piperacillin Sod-Tazob actam So Intrave… Login for More |
| 00781-3110-95 | Piperacillin and Tazobactam | Sandoz Inc | 20 | Piperacillin and Tazob actam Intravenou… Login for More |
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| •••••-••••-•• Log in to view | PIPERACILLIN AND TAZOBACTAM | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
PIPERACILLIN AND TAZOBACTAM Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Piperacillin And Tazobactam 505(b)(2) Information:
| HCPCS Code | Manufacturer | Active Ingredient | HCPCS Description |
|---|---|---|---|
| J2543 | Generic Code (Multiple Manufacturers) | Piperacillin And Tazobactam | Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams) |
PIPERACILLIN AND TAZOBACTAM CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
CMS does not include Piperacillin AND Tazobactam (J2543) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2543. Wastage billing guide →
PIPERACILLIN AND TAZOBACTAM Medically Unlikely Edits (MUE)
The most billing units of J2543 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1.125 gm. The limit is different in the office and the hospital. Use the one for your setting.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
PIPERACILLIN AND TAZOBACTAM Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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