NAFCILLIN J Code: J2291

Drug & Product Overview

HCPCS Descriptor Injection, nafcillin sodium (baxter), 20 mg

HCPCS Added Date October 1, 2025

Manufacturer Baxter Healthcare

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About NAFCILLIN

Nafcillin is a medication aligned to the HCPCS J Code: J2291 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous route and manufactured by Baxter Healthcare.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00338-1019-48	Nafcillin	Baxter Healthcare Corporation	100	2000 MG / 100 ML

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NAFCILLIN Pricing & Reimbursement

J2291 Private Payer Reimbursement

$0.15 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Nafcillin Sodium 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2290	Generic Code (Multiple Manufacturers)	Nafcillin Sodium	Injection, nafcillin sodium, 20 mg
J2291	Baxter Healthcare	Nafcillin Sodium	Injection, nafcillin sodium (baxter), 20 mg

NAFCILLIN CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

NAFCILLIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Infections caused by penicillinase-producing staphylococci

Drug Class

Penicillin-class Antibacterial [EPC]Penicillins [CS]

Frequently Asked Questions

Is there an available Nafcillin billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Nafcillin.

Are there any available Nafcillin patient assistance programs?

Our team has not identified a manufacturer-published source of patient assitance information for Nafcillin.

Where can I find Nafcillin prescribing information?

Nafcillin prescribing information can be found through the link below. Visit Here →

Where can I find Nafcillin side effect information?

Nafcillin side effect information can be found at the link below. Visit Here →

Does billing Nafcillin require wastage modifiers?

CMS does not include NAFCILLIN (J2291) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2291. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.