NUZYRA J Code: J0121

Drug & Product Overview

HCPCS Descriptor Injection, omadacycline, 1 mg

HCPCS Added Date October 1, 2019

Manufacturer Paratek Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About NUZYRA

Nuzyra is a medication aligned to the HCPCS J Code: J0121 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intravenous route and manufactured by Paratek Pharmaceuticals.

According to CMS Drug Use Information: Omadacycline is used to treat a wide variety of bacterial infections. This medication belongs to a class of drugs known as tetracycline antibiotics. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
71715-0001-02	Nuzyra	Paratek Pharmaceuticals, Inc.	1000	100 MG / 5 ML

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NUZYRA Pricing & Reimbursement

J0121 Private Payer Reimbursement

$4.13 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

NUZYRA CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Nuzyra (J0121) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

NUZYRA Medically Unlikely Edits (MUE)

The most billing units of J0121 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

200 units / day

= 200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

NUZYRA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Bacterial Skin and Skin Structure Infections Community-Acquired Bacterial Pneumonia

Drug Class

Tetracycline-class Antibacterial [EPC]Tetracyclines [CS]

Frequently Asked Questions

Is there an available Nuzyra billing and coding guide?

Billing and coding information for NUZYRA can be found through Paratek Pharmac. Visit Here →

Are there any available Nuzyra patient assistance programs?

NUZYRA patient assistance information can be found through Paratek Pharmac. Visit Here →

Where can I find Nuzyra prescribing information?

NUZYRA prescribing information can be found at the link below: Visit Here →

Where can I find Nuzyra side effect information?

Information regarding NUZYRA's side effects can be found at MedlinePlus Visit Here →

Does billing NUZYRA require JZ/JW wastage modifiers?

CMS has identified NUZYRA(J0121) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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