KIMYRSA J Code: J2406

Drug & Product Overview

HCPCS Descriptor Injection, oritavancin (kimyrsa), 10 mg

HCPCS Added Date October 1, 2021

Manufacturer Melinta Therapeutics

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About KIMYRSA

Kimyrsa is a medication aligned to the HCPCS J Code: J2406 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by Melinta Therapeutics.

According to CMS Drug Use Information: This medication is an antibiotic used to treat serious bacterial infections of the skin. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
70842-0225-01	Kimyrsa	Melinta Therapeutics, LLC	120	1200 MG / 40 ML

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KIMYRSA Pricing & Reimbursement

J2406 Private Payer Reimbursement

$43.10 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

KIMYRSA CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Kimyrsa (J2406) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

KIMYRSA Medically Unlikely Edits (MUE)

The most billing units of J2406 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

120 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

KIMYRSA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Bacterial Skin and Skin Structure Infections

Drug Class

Cytochrome P450 2C19 Inhibitors [MoA]Cytochrome P450 2C9 Inhibitors [MoA]Cytochrome P450 2D6 Inducers [MoA]Cytochrome P450 3A4 Inducers [MoA]Lipoglycopeptide Antibacterial [EPC]Lipoglycopeptides [CS]

Frequently Asked Questions

Is there an available Kimyrsa billing and coding guide?

Billing and coding information for KIMYRSA can be found through Melinta Therapeutics. Visit Here →

Are there any available Kimyrsa patient assistance programs?

KIMYRSA patient assistance information can be found through Melinta Therapeutics. Visit Here →

Where can I find Kimyrsa prescribing information?

KIMYRSA prescribing information can be found at the link below: Visit Here →

Where can I find Kimyrsa side effect information?

Our team has not yet identified a source of side effects information for KIMYRSA. Please check back in a few weeks.

Does billing KIMYRSA require JZ/JW wastage modifiers?

CMS has identified KIMYRSA(J2406) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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