ORBACTIV J Code: J2407

Drug & Product Overview

HCPCS Descriptor Injection, oritavancin (orbactiv), 10 mg

HCPCS Added Date January 1, 2016

Manufacturer Melinta Therapeutics

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About ORBACTIV

Orbactiv is a medication aligned to the HCPCS J Code: J2407 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intravenous route and manufactured by Melinta Therapeutics.

According to CMS Drug Use Information: This medication is an antibiotic used to treat serious bacterial infections of the skin. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
70842-0140-03	Orbactiv	Melinta Therapeutics, LLC	120	400 MG

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ORBACTIV Pricing & Reimbursement

J2407 Private Payer Reimbursement

$28.56 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ORBACTIV CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Orbactiv (J2407) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2407. Wastage billing guide →

ORBACTIV Medically Unlikely Edits (MUE)

The most billing units of J2407 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

120 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ORBACTIV Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Bacterial Skin and Skin Structure Infections

Drug Class

Cytochrome P450 2C19 Inhibitors [MoA]Cytochrome P450 2C9 Inhibitors [MoA]Cytochrome P450 2D6 Inducers [MoA]Cytochrome P450 3A4 Inducers [MoA]Lipoglycopeptide Antibacterial [EPC]Lipoglycopeptides [CS]

Frequently Asked Questions

Is there an available Orbactiv billing and coding guide?

Billing and coding information for ORBACTIV can be found through Melinta Therapeutics. Visit Here →

Are there any available Orbactiv patient assistance programs?

ORBACTIV patient assistance information can be found through Melinta Therapeutics. Visit Here →

Where can I find Orbactiv prescribing information?

ORBACTIV prescribing information can be found at the link below: Visit Here →

Where can I find Orbactiv side effect information?

Information regarding ORBACTIV's side effects can be found at MedlinePlus Visit Here →

Does billing ORBACTIV require JZ/JW wastage modifiers?

CMS does not include ORBACTIV (J2407) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2407. For more information, visit the link below.

About BuyandBill.com:

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