Home › Drug Codes › J Codes › J2272 · Morphine Sulfate
Updated July 1st, 2026

Morphine Sulfate J Code: J2272

Injection, morphine sulfate (fresenius kabi), not therapeutically equivalent to j2270, up to 10 mg

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Q4 2026 Medicare Payment Limit for J2272, effective October 1, 2026: $9.406 per HCPCS billing unit, up 11.2% from $8.455. From CMS's final file.

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Medicare Payment Limit ?
$8.455
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
13
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Drug & Product Overview

HCPCS Descriptor Injection, morphine sulfate (fresenius kabi), not therapeutically equivalent to j2270, up to 10 mg
HCPCS Added Date January 1, 2023
Manufacturer Fresenius Kabi
Route of Administration Intramuscular, Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About Morphine Sulfate

Morphine Sulfate is a medication aligned to the HCPCS J Code: J2272 for billing, pricing, and reimbursement purposes in the United States. It is an Opioid Analgesic drug administered via the intramuscular or intravenous routes and manufactured by Fresenius Kabi.

According to CMS Drug Use Information: This medication is used to treat severe pain. Morphine belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 13 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
63323-0451-01 Morphine Sulfate Fresenius Kabi USA, LLC 25 10 MG / 1 ML
63323-0452-01 Morphine Sulfate Fresenius Kabi USA, LLC 5 2 MG / 1 ML
63323-0454-01 Morphine Sulfate Fresenius Kabi USA, LLC 10 4 MG / 1 ML
63323-0455-01 Morphine Sulfate FreseniUS Kabi USA, LLC 13 5 MG
76045-0004-11 Morphine Sulfate Fresenius Kabi, USA LLC 2 2 MG / 1 ML
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Morphine Sulfate
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Morphine Sulfate Pricing & Reimbursement

J2272 Private Payer Reimbursement
$7.07 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Morphine Sulfate 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2270 Generic Code (Multiple Manufacturers) Morphine Sulfate Injection, morphine sulfate, up to 10 mg
J2272 Fresenius Kabi Morphine Sulfate Injection, morphine sulfate (fresenius kabi), not therapeutically equivalent to j2270, up to 10 mg
J2274 Generic Code (Multiple Manufacturers) Morphine Sulfate Injection, morphine sulfate, preservative-free for epidural or intrathecal use, 10 mg

Morphine Sulfate CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
JW / JZ modifiers apply

CMS has identified Morphine Sulfate (J2272) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

Morphine Sulfate Medically Unlikely Edits (MUE)

The most billing units of J2272 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
9 units / day
= 90 mg per day
Hospital Outpatient
15 units / day
= 150 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Morphine Sulfate Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Pain severe enough to require an opioid analgesic pain severe enough to require an opioid analgesic
Drug Class
Full Opioid Agonists [MoA]Opioid Agonist [EPC]

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Frequently Asked Questions

Is there an available Morphine Sulfate billing and coding guide?
We have not yet identified a manufacturer source of Morphine Sulfate billing and coding information.
Are there any available Morphine Sulfate patient assistance programs?
Our team did not identify a source for Morphine Sulfate patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Morphine Sulfate prescribing information?
Morphine Sulfate prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Morphine Sulfate side effect information?
Our team has not yet identified a source of side effects information for Morphine Sulfate. Please check back in a few weeks.
Does billing Morphine Sulfate require JZ/JW wastage modifiers?
CMS has identified Morphine Sulfate(J2272) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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