Home › Drug Codes › J Codes › J2300 · NALBUPHINE HCL
Updated July 1st, 2026

NALBUPHINE HCL J Code: J2300

Injection, nalbuphine hydrochloride, per 10 mg

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Q4 2026 Medicare Payment Limit for J2300, effective October 1, 2026: $4.071 per HCPCS billing unit, down 5.0% from $4.287. From CMS's final file.

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Medicare Payment Limit ?
$4.287
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
13
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Drug & Product Overview

HCPCS Descriptor Injection, nalbuphine hydrochloride, per 10 mg
HCPCS Added Date January 1, 1996
Manufacturer Multiple Manufacturers
Route of Administration Intramuscular, Intravenous, Subcutaneous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose, Multi-Dose
Dosage Form Injection | Injection, Solution

About NALBUPHINE HCL

Nalbuphine HCL is a medication aligned to the HCPCS J Code: J2300 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Addiction, it is administered via the intramuscular, intravenous, or subcutaneous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 13 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00409-1463-01 Nalbuphine Hydrochloride Hospira, Inc. 10 10 MG / 1 ML
00409-1463-49 Nalbuphine Hydrochloride Hospira, Inc. 10 10 MG / 1 ML
00409-1465-01 Nalbuphine Hydrochloride Hospira, Inc. 20 20 MG / 1 ML
00409-1467-01 Nalbuphine Hydrochloride Hospira, Inc. 500 200 MG / 10 ML
70069-0661-10 Nalbuphine hydrochloride Somerset Therapeutics, LLC 100 100 MG / 10 ML
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NALBUPHINE HCL
NALBUPHINE HCL
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NALBUPHINE HCL Pricing & Reimbursement

J2300 Private Payer Reimbursement
$3.40 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

NALBUPHINE HCL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Nalbuphine HCL (J2300) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2300. Wastage billing guide →

NALBUPHINE HCL Medically Unlikely Edits (MUE)

The most billing units of J2300 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
4 units / day
= 40 mg per day
Hospital Outpatient
10 units / day
= 100 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

NALBUPHINE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Obstetrical analgesia during labor and delivery Pain Postoperative analgesia Preoperative analgesia Supplement to balanced anesthesia balanced anesthesia supplement obstetrical analgesia during labor and delivery pain pain severe enough to require an opioid analgesic postoperative analgesia preoperative analgesia preoperative and postoperative analgesia supplement to balanced anesthesia
Drug Class
Competitive Opioid Antagonists [MoA]Opioid Agonist/Antagonist [EPC]Partial Opioid Agonists [MoA]

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Frequently Asked Questions

Is there an available Nalbuphine Hcl billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for NALBUPHINE HCL.
Are there any available Nalbuphine Hcl patient assistance programs?
NALBUPHINE HCL patient assistance information can be found through Pfizer. Visit Here →
Where can I find Nalbuphine Hcl prescribing information?
NALBUPHINE HCL prescribing information can be found at the link below: Visit Here →
Where can I find Nalbuphine Hcl side effect information?
Information regarding NALBUPHINE HCL's side effects can be found at MedlinePlus Visit Here →
Does billing NALBUPHINE HCL require JZ/JW wastage modifiers?
CMS does not include NALBUPHINE HCL (J2300) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2300. For more information, visit the link below.

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