Home › Drug Codes › J Codes › J0592 · BUPRENEX

Updated July 1st, 2026

BUPRENEX J Code: J0592

Injection, buprenorphine hydrochloride, 0.1 mg

Medicare Payment Limit ?

$4.474

/ HCPCS billing unit · Q3 2026

APC Payment Limit ?

Not published

CMS publishes none for Q3 2026

ASP ?

$•••.••

WAC · AWP ?

$•••.••

NDCs Crosswalked ?

View NDC crosswalk →

Drug & Product Overview

HCPCS Descriptor Injection, buprenorphine hydrochloride, 0.1 mg

HCPCS Added Date January 1, 2003

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Solution

About BUPRENEX

Buprenex is a medication aligned to the HCPCS J Code: J0592 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Addiction drug administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Buprenorphine is used to help relieve moderate to severe pain. Buprenorphine belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 4 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00409-2012-32	Buprenorphine Hydrochloride	Hospira, Inc.	30	0.3 MG / 1 ML
42023-0179-05	Buprenorphine Hydrochloride	Par Health USA, LLC	15	0.324 MG / 1 ML
70069-0027-05	Buprenorphine Hydrochloride	Somerset Therapeutics, LLC	15	0.324 MG / 1 ML
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Login to view 1 more NDC package View pricing, complete NDC-to-HCPCS alignments, and package details.

BUPRENEX Pricing & Reimbursement

J0592 Private Payer Reimbursement

$4.16 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

BUPRENEX CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

JW / JZ modifiers apply

CMS has identified Buprenex (J0592) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

BUPRENEX Medically Unlikely Edits (MUE)

The most billing units of J0592 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

6 units / day

= 0.6 mg per day

Hospital Outpatient

12 units / day

= 1.2 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

BUPRENEX Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

pain severe enough to require an opioid analgesic

Drug Class

Partial Opioid Agonist [EPC]Partial Opioid Agonists [MoA]

Frequently Asked Questions

Is there an available Buprenex billing and coding guide?

We have not yet identified a manufacturer source of Buprenex billing and coding information.

Are there any available Buprenex patient assistance programs?

Our team did not identify a source for Buprenex patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Buprenex prescribing information?

Our team is still working to identify a prescribing information source for BUPRENEX

Where can I find Buprenex side effect information?

Our team has not yet identified a source of side effects information for BUPRENEX. Please check back in a few weeks.

Does billing BUPRENEX require JZ/JW wastage modifiers?

CMS has identified BUPRENEX(J0592) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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BUPRENEX Pricing

Q3 2026

J0592

Medicare Payment Limit per HCPCS unit

$4.474

Medicare Co-Insurance20% · per HCPCS unit $0.89

APC Payment Limit per HCPCS unit

Not published

ASP · WAC · AWP per HCPCS unit and NDC package

NDC Crosswalk

4 NDCs

00409-2012-32 · 42023-0179-05 · 70069-0027-05 · +1 more View full NDC crosswalk →

For manufacturers

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