METHADONE HCL S Code: S0109

Drug & Product Overview

HCPCS Descriptor Methadone, oral, 5 mg

HCPCS Added Date October 1, 2004

Manufacturer Ascend Laboratories

Route of Administration Oral

Generic Status Single-Source; Branded

Dosage Form Tablet

About METHADONE HCL

Methadone HCL is a medication aligned to the HCPCS S Code: S0109 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Addiction drug administered via the oral route and manufactured by Ascend Laboratories.

Manufacturers, reach out to us to add more information.

NDC Code Information

1 NDC package is crosswalked to S0109. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	METHADONE HCL

Login to view 1 NDC package View pricing, complete NDC-to-HCPCS alignments, and package details.

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METHADONE HCL Pricing & Reimbursement

S0109 Private Payer Reimbursement

$0.22 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Not on the CMS JW / JZ list

CMS does not include Methadone HCL (S0109) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing S0109. Wastage billing guide →

METHADONE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Opioid addiction – detoxification Opioid addiction – maintenance treatment Severe and persistent pain

Drug Class

Full Opioid Agonists [MoA]Opioid Agonist [EPC]

Frequently Asked Questions

Is there an available Methadone Hcl billing and coding guide?

We have not yet identified a manufacturer source of Methadone Hcl billing and coding information.

Are there any available Methadone Hcl patient assistance programs?

Our team did not identify a source for Methadone Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Methadone Hcl prescribing information?

METHADONE HCL prescribing information can be found at the link below: Visit Here →

Where can I find Methadone Hcl side effect information?

Information regarding METHADONE HCL's side effects can be found at MedlinePlus Visit Here →

Does billing METHADONE HCL require JZ/JW wastage modifiers?

CMS does not include METHADONE HCL (S0109) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing S0109. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.