ZINPLAVA J Code: J0565

Drug & Product Overview

HCPCS Descriptor Injection, bezlotoxumab, 10 mg

HCPCS Added Date January 1, 2018

Manufacturer Merck Sharp & Dohme Corp

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About ZINPLAVA

Zinplava is a medication aligned to the HCPCS J Code: J0565 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the intravenous route and manufactured by Merck Sharp & Dohme Corp.

According to CMS Drug Use Information: Bezlotoxumab is used to prevent the return of a severe intestinal infection due to a bacteria called C. difficile. Bezlotoxumab belongs to a class of drugs known as monoclonal antibodies. It works by blocking the effects of toxins made by C. difficile bacteria during an infection. Bezlotoxumab is not an antibiotic and will not work to treat bacterial infections. Your doctor will prescribe a separate antibiotic to treat your C. difficile infection. Carefully follow your doctor's directions for all your medications.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

2 NDC packages are crosswalked to J0565. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	ZINPLAVA
	ZINPLAVA

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ZINPLAVA Pricing & Reimbursement

J0565 Private Payer Reimbursement

$39.64 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

ZINPLAVA CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Zinplava (J0565) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ZINPLAVA Medically Unlikely Edits (MUE)

The most billing units of J0565 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

200 units / day

= 2,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ZINPLAVA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Clostridioides difficile infection (CDI) recurrence reduction

Frequently Asked Questions

Is there an available Zinplava billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for ZINPLAVA.

Are there any available Zinplava patient assistance programs?

ZINPLAVA patient assistance information can be found through Merck. Visit Here →

Where can I find Zinplava prescribing information?

ZINPLAVA prescribing information can be found at the link below: Visit Here →

Where can I find Zinplava side effect information?

Information regarding ZINPLAVA's side effects can be found at MedlinePlus Visit Here →

Does billing ZINPLAVA require JZ/JW wastage modifiers?

CMS has identified ZINPLAVA(J0565) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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