ZEMDRI J Code: J0291

Drug & Product Overview

HCPCS Descriptor Injection, plazomicin, 5 mg

HCPCS Added Date October 1, 2019

Manufacturer Cipla

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About ZEMDRI

Zemdri is a medication aligned to the HCPCS J Code: J0291 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by Cipla.

According to CMS Drug Use Information: This medication is used to treat a variety of bacterial infections. Plazomicin belongs to a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 4 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
69097-0820-96	Zemdri (plazomicin)	Cipla USA Inc.	1000	500 MG / 10 ML
•••••-••••-•• Log in to view	ZEMDRI
	ZEMDRI
	ZEMDRI

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ZEMDRI Pricing & Reimbursement

J0291 Private Payer Reimbursement

$3.40 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ZEMDRI CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Zemdri (J0291) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ZEMDRI Medically Unlikely Edits (MUE)

The most billing units of J0291 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.

Practitioner Office & Hospital Outpatient

500 units / day

= 2,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ZEMDRI Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Complicated Urinary Tract Infections (cUTI), including Pyelonephritis

Frequently Asked Questions

Is there an available Zemdri billing and coding guide?

Billing and coding information for ZEMDRI can be found through Cipla. Visit Here →

Are there any available Zemdri patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for ZEMDRI.

Where can I find Zemdri prescribing information?

ZEMDRI prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Zemdri side effect information?

Our team has not yet identified a source of side effects information for ZEMDRI. Please check back in a few weeks.

Does billing ZEMDRI require JZ/JW wastage modifiers?

CMS has identified ZEMDRI(J0291) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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