AZITHROMYCIN J Code: J0456

Drug & Product Overview

HCPCS Descriptor Injection, azithromycin, 500 mg

HCPCS Added Date January 1, 2000

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About AZITHROMYCIN

Azithromycin is a medication aligned to the HCPCS J Code: J0456 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Azithromycin is used to treat a wide variety of bacterial infections. It is known as a macrolide antibiotic. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 16 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00069-3150-83	Zithromax	Pfizer Laboratories Div Pfizer Inc	10	500 MG / 5 ML
00409-0144-11	Azithromycin	Pfizer Inc	10	500 MG
25021-0180-66	Azithromycin	Sagent Pharmaceuticals	10	500 MG / 5 ML
55150-0174-10	Azithromycin	Eugia Us Llc	10	500 MG
63323-0398-10	Azithromycin	Fresenius Kabi USA, LLC	10	500 MG / 5 ML
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AZITHROMYCIN Pricing & Reimbursement

J0456 Private Payer Reimbursement

$2.05 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

AZITHROMYCIN CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Azithromycin (J0456) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

AZITHROMYCIN Medically Unlikely Edits (MUE)

The most billing units of J0456 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 500 mg.

Practitioner Office & Hospital Outpatient

4 units / day

= 2,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

AZITHROMYCIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Community-Acquired Pneumonia Pelvic Inflammatory Disease

Drug Class

Macrolide Antimicrobial [EPC]Macrolides [CS]

Frequently Asked Questions

Is there an available Azithromycin billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for AZITHROMYCIN.

Are there any available Azithromycin patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for AZITHROMYCIN.

Where can I find Azithromycin prescribing information?

AZITHROMYCIN prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Azithromycin side effect information?

Our team has not yet identified a source of side effects information for AZITHROMYCIN. Please check back in a few weeks.

Does billing AZITHROMYCIN require JZ/JW wastage modifiers?

CMS has identified AZITHROMYCIN(J0456) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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