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Updated July 1st, 2026

Linezolid J Code: J2021

Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg

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Q4 2026 Medicare Payment Limit for J2021, effective October 1, 2026: $31.611 per HCPCS billing unit, down 7.5% from $34.175. From CMS's final file.

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Medicare Payment Limit ?
$34.175
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg
HCPCS Added Date January 1, 2023
Manufacturer Hospira
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About Linezolid

Linezolid is a medication aligned to the HCPCS J Code: J2021 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous route and manufactured by Hospira.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00409-4883-01 Linezolid Pfizer Inc 30 0.9 MG / 300 ML
00409-4883-10 Linezolid Hospira, Inc. 30 600 MG / 300 ML
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Linezolid Pricing & Reimbursement

J2021 Private Payer Reimbursement
$22.06 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Linezolid 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2020 Generic Code (Multiple Manufacturers) Linezolid Injection, linezolid, 200 mg
J2021 Generic Code (Multiple Manufacturers) Linezolid Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg

Linezolid CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

CMS does not include Linezolid (J2021) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2021. Wastage billing guide →

Linezolid Medically Unlikely Edits (MUE)

The most billing units of J2021 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 200 mg.

Practitioner Office & Hospital Outpatient
6 units / day
= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Linezolid Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Community-acquired Pneumonia Complicated Skin and Skin Structure Infections Nosocomial Pneumonia Vancomycin-resistant Enterococcus faecium Infections
Drug Class
Oxazolidinone Antibacterial [EPC]Oxazolidinones [CS]

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Frequently Asked Questions

Is there an available Linezolid billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for Linezolid.
Are there any available Linezolid patient assistance programs?
Linezolid patient assistance information can be found through Pfizer. Visit Here →
Where can I find Linezolid prescribing information?
Linezolid prescribing information can be found at the link below: Visit Here →
Where can I find Linezolid side effect information?
Information regarding Linezolid's side effects can be found at MedlinePlus Visit Here →
Does billing Linezolid require JZ/JW wastage modifiers?
CMS does not include Linezolid (J2021) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2021. For more information, visit the link below.

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