Linezolid J Code: J2021

Drug & Product Overview

HCPCS Descriptor Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg

HCPCS Added Date January 1, 2023

Manufacturer Pfizer

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About Linezolid

Linezolid is a medication aligned to the HCPCS J Code: J2021 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous route and manufactured by Pfizer.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00409-4883-01	Linezolid	Pfizer Inc	30	0.9 MG / 300 ML
00409-4883-10	Linezolid	Hospira, Inc.	30	600 MG / 300 ML
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Linezolid Pricing & Reimbursement

J2021 Private Payer Reimbursement

$22.06 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Linezolid 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2020	Generic Code (Multiple Manufacturers)	Linezolid	Injection, linezolid, 200 mg
J2021	Pfizer	Linezolid	Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg

Linezolid CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Linezolid (J2021) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2021. Wastage billing guide →

Linezolid Medically Unlikely Edits (MUE)

The most billing units of J2021 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 200 mg.

Practitioner Office & Hospital Outpatient

6 units / day

= 1,200 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Linezolid Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Community-acquired Pneumonia Complicated Skin and Skin Structure Infections Nosocomial Pneumonia Vancomycin-resistant Enterococcus faecium Infections

Drug Class

Oxazolidinone Antibacterial [EPC]Oxazolidinones [CS]

Frequently Asked Questions

Is there an available Linezolid billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Linezolid.

Are there any available Linezolid patient assistance programs?

Linezolid patient assistance information can be found through Pfizer. Visit Here →

Where can I find Linezolid prescribing information?

Linezolid prescribing information can be found at the link below: Visit Here →

Where can I find Linezolid side effect information?

Information regarding Linezolid's side effects can be found at MedlinePlus Visit Here →

Does billing Linezolid require JZ/JW wastage modifiers?

CMS does not include Linezolid (J2021) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2021. For more information, visit the link below.

About BuyandBill.com:

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