CUBICIN RF J Code: J0878
Injection, daptomycin, 1 mg
Q4 2026 Medicare Payment Limit for J0878, effective October 1, 2026: $0.027 per HCPCS billing unit, down 6.9% from $0.029. From CMS's final file.
Drug & Product Overview
About CUBICIN RF
Cubicin RF is a medication aligned to the HCPCS J Code: J0878 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous route and manufactured by multiple companies.
According to CMS Drug Use Information: This medication is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. Daptomycin is not recommended for use in children younger than 12 months due to possible risk of serious side effects.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 38 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00143-9378-01 | Daptomycin | Hikma Pharmaceuticals USA Inc. | 500 | 500 MG / 10 ML |
| 16714-0892-01 | Daptomycin | NorthStar RxLLC | 500 | 750 MG / 15 ML |
| 16729-0434-05 | Daptomycin | Accord Healthcare, Inc. | 350 | 350 MG / 7 ML |
| 16729-0435-05 | Daptomycin | Accord Healthcare Inc. | 500 | 500 MG / 10 ML |
| 25021-0174-15 | daptomycin | Sagent Pharmaceuticals | 500 | 500 MG / 10 ML |
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CUBICIN RF Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Daptomycin 505(b)(2) Information:
| HCPCS Code | Manufacturer | Active Ingredient | HCPCS Description |
|---|---|---|---|
| J0871 | Par Pharmaceutical, Inc | Daptomycin | Injection, daptomycin (endo), not therapeutically equivalent to j0878, 1 mg |
| J0872 | Generic Code (Multiple Manufacturers) | Daptomycin | Injection, daptomycin (xellia), unrefrigerated, not therapeutically equivalent to j0878 or j0873, 1 mg |
| J0873 | Generic Code (Multiple Manufacturers) | Daptomycin | Injection, daptomycin (xellia), not therapeutically equivalent to j0878 or j0872, 1 mg |
| J0874 | Baxter Healthcare | Daptomycin | Injection, daptomycin (baxter), not therapeutically equivalent to j0878, 1 mg |
| J0877 | Generic Code (Multiple Manufacturers) | Daptomycin | Injection, daptomycin (hospira), not therapeutically equivalent to j0878, 1 mg |
| J0878 | Generic Code (Multiple Manufacturers) | Daptomycin | Injection, daptomycin, 1 mg |
CUBICIN RF CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
CMS has identified Cubicin RF (J0878) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →
CUBICIN RF Medically Unlikely Edits (MUE)
The most billing units of J0878 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
CUBICIN RF Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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