XENPOZYME J Code: J0218

Drug & Product Overview

HCPCS Descriptor Injection, olipudase alfa-rpcp, 1 mg

HCPCS Added Date April 1, 2023

Manufacturer Sanofi

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About XENPOZYME

Xenpozyme is a medication aligned to the HCPCS J Code: J0218 for billing, pricing, and reimbursement purposes in the United States. Classified under Enzyme Replacement Therapy, it is administered via the intravenous route and manufactured by Sanofi.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
58468-0050-01	Xenpozyme	Genzyme Corporation	20	20 MG / 5.1 ML
58468-0051-01	Xenpozyme	Genzyme Corporation	4	4 MG / 1.1 ML

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XENPOZYME Pricing & Reimbursement

J0218 Private Payer Reimbursement

$395.39 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

XENPOZYME CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Xenpozyme (J0218) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

XENPOZYME Medically Unlikely Edits (MUE)

The most billing units of J0218 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

460 units / day

= 460 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

XENPOZYME Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acid sphingomyelinase deficiency (ASMD), non–central nervous system manifestations

Frequently Asked Questions

Is there an available Xenpozyme billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for XENPOZYME.

Are there any available Xenpozyme patient assistance programs?

XENPOZYME patient assistance information can be found through Genzyme. Visit Here →

Where can I find Xenpozyme prescribing information?

XENPOZYME prescribing information can be found at the link below: Visit Here →

Where can I find Xenpozyme side effect information?

Our team has not yet identified a source of side effects information for XENPOZYME. Please check back in a few weeks.

Does billing XENPOZYME require JZ/JW wastage modifiers?

CMS has identified XENPOZYME(J0218) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

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