ARALAST NP J Code: J0256

Drug & Product Overview

HCPCS Descriptor Injection, alpha 1 proteinase inhibitor (human), not otherwise specified, 10 mg

HCPCS Added Date January 1, 1989

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Solution | Kit | Not Available

About ARALAST NP

Aralast NP is a medication aligned to the HCPCS J Code: J0256 for billing, pricing, and reimbursement purposes in the United States. It is an Enzyme Replacement Therapy drug administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat lung problems (emphysema) caused by a certain inherited disease (alpha-1-proteinase inhibitor deficiency). In people with this condition, lung damage is caused by elastase, a natural substance that the body needs to kill bacteria in the lungs. Normally, a protein (alpha-1-proteinase inhibitor) stops elastase from working when it is no longer needed. However, in people who do not make enough of this protein, elastase does not stop working and damages the lungs. This medication replaces the missing alpha-1-proteinase inhibitor and helps to prevent further lung damage.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 8 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00053-7201-02	Zemaira	CSL Behring LLC	0.1	Kit
00053-7202-02	Zemaira	CSL Behring LLC	0.1	Kit
00053-7203-02	Zemaira	CSL Behring LLC	0.1	Kit
00944-2814-01	Aralast NP	Takeda Pharmaceuticals America, Inc.	0.1	Kit
13533-0705-01	Prolastin-C Liquid	GRIFOLS USA, LLC	0.1	1000 MG / 20 ML
•••••-••••-•• Log in to view	ARALAST NP
	ARALAST NP
	ARALAST NP

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ARALAST NP Pricing & Reimbursement

J0256 Private Payer Reimbursement

$5.30 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ARALAST NP Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 20.22%

Avg. Days to File 6.8days

Avg. Days to Pay 23.5days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J0256 claims analytics on FocalPoint →

ARALAST NP CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Aralast NP (J0256) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0256. Wastage billing guide →

ARALAST NP Medically Unlikely Edits (MUE)

The most billing units of J0256 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

1,600 units / day

= 16,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ARALAST NP Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

A1-PI deficiency with clinical evidence of emphysema emphysema due to severe congenital deficiency of Alpha 1-Proteinase Inhibitor (alpha 1-antitrypsin deficiency) emphysema due to severe hereditary deficiency of Alpha 1-Proteinase Inhibitor (alpha 1-antitrypsin deficiency)

Drug Class

Human alpha-1 Proteinase Inhibitor [EPC]Trypsin Inhibitors [MoA]

Frequently Asked Questions

Is there an available Aralast Np billing and coding guide?

Billing and coding information for ARALAST NP can be found through Multiple Manufacturers. Visit Here →

Are there any available Aralast Np patient assistance programs?

ARALAST NP patient assistance information can be found through Multiple Manufacturers. Visit Here →

Where can I find Aralast Np prescribing information?

Our team is still working to identify a prescribing information source for ARALAST NP

Where can I find Aralast Np side effect information?

Our team has not yet identified a source of side effects information for ARALAST NP. Please check back in a few weeks.

Does billing ARALAST NP require JZ/JW wastage modifiers?

CMS does not include ARALAST NP (J0256) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0256. For more information, visit the link below.

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