GLASSIA J Code: J0257

Drug & Product Overview

HCPCS Descriptor Injection, alpha 1 proteinase inhibitor (human), (glassia), 10 mg

HCPCS Added Date January 1, 2012

Manufacturer Takeda Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About GLASSIA

Glassia is a medication aligned to the HCPCS J Code: J0257 for billing, pricing, and reimbursement purposes in the United States. Classified under Enzyme Replacement Therapy, it is administered via the intravenous route and manufactured by Takeda Pharmaceuticals.

According to CMS Drug Use Information: This medication is used to treat lung problems (emphysema) caused by a certain inherited disease (alpha-1-proteinase inhibitor deficiency). In people with this condition, lung damage is caused by elastase, a natural substance that the body needs to kill bacteria in the lungs. Normally, a protein (alpha-1-proteinase inhibitor) stops elastase from working when it is no longer needed. However, in people who do not make enough of this protein, elastase does not stop working and damages the lungs. This medication replaces the missing alpha-1-proteinase inhibitor and helps to prevent further lung damage.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 6 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00944-2884-01	Glassia	Takeda Pharmaceuticals America, Inc.	0.1	1000 MG / 50 ML
00944-2884-03	Glassia	Takeda Pharmaceuticals America, Inc.	0.1	1000 MG / 50 ML
00944-2884-05	Glassia	Takeda Pharmaceuticals America, Inc.	0.1	1000 MG / 50 ML
•••••-••••-•• Log in to view	GLASSIA
	GLASSIA
	GLASSIA

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GLASSIA Pricing & Reimbursement

J0257 Private Payer Reimbursement

$5.53 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

GLASSIA CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Glassia (J0257) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

GLASSIA Medically Unlikely Edits (MUE)

The most billing units of J0257 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

1,400 units / day

= 14,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

GLASSIA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

emphysema due to severe hereditary deficiency of Alpha 1-Proteinase Inhibitor (Alpha 1-antitrypsin deficiency)

Drug Class

Human alpha-1 Proteinase Inhibitor [EPC]Trypsin Inhibitors [MoA]

Frequently Asked Questions

Is there an available Glassia billing and coding guide?

Billing and coding information for GLASSIA can be found through Baxalta. Visit Here →

Are there any available Glassia patient assistance programs?

GLASSIA patient assistance information can be found through Baxalta. Visit Here →

Where can I find Glassia prescribing information?

GLASSIA prescribing information can be found at the link below: Visit Here →

Where can I find Glassia side effect information?

Our team has not yet identified a source of side effects information for GLASSIA. Please check back in a few weeks.

Does billing GLASSIA require JZ/JW wastage modifiers?

CMS has identified GLASSIA(J0257) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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