FABRAZYME J Code: J0180

Drug & Product Overview

HCPCS Descriptor Injection, agalsidase beta, 1 mg

HCPCS Added Date January 1, 2005

Manufacturer Genzyme

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About FABRAZYME

Fabrazyme is a medication aligned to the HCPCS J Code: J0180 for billing, pricing, and reimbursement purposes in the United States. This Enzyme Replacement Therapy medication is administered via the intravenous route and manufactured by Genzyme.

According to CMS Drug Use Information: This medication is used to treat a certain inherited disorder (Fabry disease) that causes buildup of a certain fat substance (GL-3) in some parts of your body. Worsening of this disorder can lead to kidney disease, heart attack, or stroke. Agalsidase beta works by replacing an enzyme that your body lacks, which helps break down the fat substance (GL-3) in your body. This can help prevent symptoms such as pain (especially in the hands and feet), dark red spots on the skin, a decreased ability to sweat, cloudiness of the front part of the eye, stomach/intestinal problems, ringing in the ears (tinnitus), and hearing loss.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
58468-0040-01	Fabrazyme	Genzyme Corporation	35	35 MG / 7 ML
58468-0041-01	Fabrazyme	Genzyme Corporation	5	5 MG / 1 ML

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FABRAZYME Pricing & Reimbursement

J0180 Private Payer Reimbursement

$230.24 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

FABRAZYME CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Fabrazyme (J0180) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0180. Wastage billing guide →

FABRAZYME Medically Unlikely Edits (MUE)

The most billing units of J0180 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

140 units / day

= 140 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

FABRAZYME Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Fabry disease

Drug Class

Hydrolytic Lysosomal Neutral Glycosphingolipid-specific Enzyme [EPC]alpha-Glucosidases [CS]

Frequently Asked Questions

Is there an available Fabrazyme billing and coding guide?

Billing and coding information for FABRAZYME can be found through Genzyme. Visit Here →

Are there any available Fabrazyme patient assistance programs?

FABRAZYME patient assistance information can be found through Genzyme. Visit Here →

Where can I find Fabrazyme prescribing information?

FABRAZYME prescribing information can be found at the link below: Visit Here →

Where can I find Fabrazyme side effect information?

Information regarding FABRAZYME's side effects can be found at MedlinePlus Visit Here →

Does billing FABRAZYME require JZ/JW wastage modifiers?

CMS does not include FABRAZYME (J0180) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0180. For more information, visit the link below.

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