SULFAMETHOXAZOLE-TRIMETHOPRIM J Code: J2865

Drug & Product Overview

HCPCS Descriptor Injection, sulfamethoxazole 5 mg and trimethoprim 1 mg

HCPCS Added Date April 1, 2025

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose, Multi-Dose

Dosage Form Injection, Solution, Concentrate | Not Available

About SULFAMETHOXAZOLE-TRIMETHOPRIM

Sulfamethoxazole-trimethoprim is a medication aligned to the HCPCS J Code: J2865 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 14 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00703-9503-03	Sulfamethoxazole and Trimethoprim	Teva Parenteral Medicines, Inc.	800	400 MG / 5 ML
00703-9514-03	Sulfamethoxazole and Trimethoprim	Teva Parenteral Medicines, Inc.	1600	800 MG / 10 ML
00703-9526-01	Sulfamethoxazole and Trimethoprim	Teva Parenteral Medicines, Inc.	480	2400 MG / 30 ML
67457-0921-05	Sulfamethoxazole-Trimethoprim	Mylan Institutional LLC	800	80 MG / 5 ML
70069-0361-10	Sulfamethoxazole and Trimethoprim	Somerset Therapeutics, LLC	800	400 MG / 5 ML
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	SULFAMETHOXAZOLE-TRIMETHOPRIM
	SULFAMETHOXAZOLE-TRIMETHOPRIM

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SULFAMETHOXAZOLE-TRIMETHOPRIM Pricing & Reimbursement

J2865 Private Payer Reimbursement

$0.04 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Sulfamethoxazole And Trimethoprim 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2865	Generic Code (Multiple Manufacturers)	Sulfamethoxazole And Trimethoprim	Injection, sulfamethoxazole 5 mg and trimethoprim 1 mg

SULFAMETHOXAZOLE-TRIMETHOPRIM CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

SULFAMETHOXAZOLE-TRIMETHOPRIM Medically Unlikely Edits (MUE)

The most billing units of J2865 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5mg-1mg.

Practitioner Office & Hospital Outpatient

3,000 units / day

= 15,000 mg-1mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

SULFAMETHOXAZOLE-TRIMETHOPRIM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Urinary tract infections Acute otitis media Acute exacerbations of chronic bronchitis Traveler’s diarrhea Shigellosis Pneumocystis jirovecii pneumonia (treatment and prophylaxis)

Drug Class

Cytochrome P450 2C8 Inhibitors [MoA]Cytochrome P450 2C9 Inhibitors [MoA]Dihydrofolate Reductase Inhibitor Antibacterial [EPC]Dihydrofolate Reductase Inhibitors [MoA]Organic Cation Transporter 2 Inhibitors [MoA]Sulfonamide Antimicrobial [EPC]Sulfonamides [CS]

Frequently Asked Questions

Is there a manufacturer-published SULFAMETHOXAZOLE-TRIMETHOPRIM billing and coding guide?

Our team has not identified a manufacturer-published billing and coding guide for SULFAMETHOXAZOLE-TRIMETHOPRIM.

What are the available SULFAMETHOXAZOLE-TRIMETHOPRIM patient assistance programs?

Our team has not identified a source of patient assitsance information for SULFAMETHOXAZOLE-TRIMETHOPRIM.

Where can I find SULFAMETHOXAZOLE-TRIMETHOPRIM prescribing information?

Our team has not identified a source of prescribing information for SULFAMETHOXAZOLE-TRIMETHOPRIM.

Where can I find SULFAMETHOXAZOLE-TRIMETHOPRIM side effect information?

Our team has not identified a source of side effect information for SULFAMETHOXAZOLE-TRIMETHOPRIM.

Does billing SULFAMETHOXAZOLE-TRIMETHOPRIM require JZ/JW wastage modifiers?

CMS does not include SULFAMETHOXAZOLE-TRIMETHOPRIM (J2865) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2865. For more information, visit the link below.

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