LEUKINE J Code: J2820

Drug & Product Overview

HCPCS Descriptor Injection, sargramostim (gm-csf), 50 mcg

HCPCS Added Date January 1, 1982

Manufacturer Partner Therapeutics, Inc

Route of Administration Intravenous, Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About LEUKINE

Leukine is a medication aligned to the HCPCS J Code: J2820 for billing, pricing, and reimbursement purposes in the United States. This Oncology Colony Stimulating Factor medication is administered via the intravenous or subcutaneous routes and manufactured by Partner Therapeutics, Inc.

According to CMS Drug Use Information: Sargramostim is a man-made version of a certain natural substance made in your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Sargramostim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy or exposure to large amounts of radiation). It is also used in certain treatment procedures (such as bone marrow/stem cell transplant).

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
71837-5843-05	Leukine	Partner Therapeutics, Inc.	25	250 MCG / 1 ML

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LEUKINE Pricing & Reimbursement

J2820 Private Payer Reimbursement

$63.31 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

LEUKINE Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 18.93%

Avg. Days to File 10.4days

Avg. Days to Pay 25.7days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2820 claims analytics on FocalPoint →

LEUKINE CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

JW / JZ modifiers apply

CMS has identified Leukine (J2820) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

LEUKINE Medically Unlikely Edits (MUE)

The most billing units of J2820 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mcg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

15 units / day

= 750 mcg per day

Hospital Outpatient

10 units / day

= 500 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

LEUKINE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Myeloid Leukemia Allogeneic Bone Marrow Transplantation Autologous Bone Marrow Transplantation Autologous Peripheral Blood Progenitor Cell Mobilization and Collection Autologous Peripheral Blood Progenitor Cell Transplantation Delayed Neutrophil Recovery or Graft Failure Following Bone Marrow Transplantation Hematopoietic Syndrome of Acute Radiation Syndrome (H-ARS)

Drug Class

Granulocyte Colony-Stimulating Factor [CS]Granulocyte-Macrophage Colony-Stimulating Factor [CS]Increased Myeloid Cell Production [PE]Leukocyte Growth Factor [EPC]

Frequently Asked Questions

Is there an available Leukine billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for LEUKINE.

Are there any available Leukine patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for LEUKINE.

Where can I find Leukine prescribing information?

LEUKINE prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Leukine side effect information?

Our team has not yet identified a source of side effects information for LEUKINE. Please check back in a few weeks.

Does billing LEUKINE require JZ/JW wastage modifiers?

CMS has identified LEUKINE(J2820) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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