Home › Drug Codes › Q Codes › Q5101 · ZARXIO
Updated July 1st, 2026

ZARXIO Q Code: Q5101

Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram

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Q4 2026 Medicare Payment Limit for Q5101, effective October 1, 2026: $0.338 per HCPCS billing unit, down 4.2% from $0.353. From CMS's final file.

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Medicare Payment Limit ?
$0.353
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$0.353
/ HCPCS billing unit · APC 1822
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram
HCPCS Added Date July 1, 2015
Manufacturer Sandoz
Route of Administration Intravenous, Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About ZARXIO

Zarxio is a medication aligned to the HCPCS Q Code: Q5101 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology Colony Stimulating Factor, it is administered via the intravenous or subcutaneous routes and manufactured by Sandoz.

According to CMS Drug Use Information: Filgrastim is a man-made version of a certain natural substance made by your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Filgrastim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy, chronic neutropenia, or exposure to large amounts of radiation). It is also used in certain treatment procedures (such as bone marrow/stem cell transplant). This monograph is about the following filgrastim products: filgrastim, filgrastim-aafi, filgrastim-ayow, filgrastim-laha, filgrastim-sndz, filgrastim-txid, and tbo-filgrastim.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
61314-0318-01 Zarxio Sandoz Inc. 300 300 MCG / 0.5 ML
61314-0318-10 Zarxio Sandoz Inc. 3000 300 MCG / 0.5 ML
61314-0326-01 Zarxio Sandoz Inc. 480 480 MCG / 0.8 ML
61314-0326-10 Zarxio Sandoz Inc. 4800 480 MCG / 0.8 ML
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ZARXIO Pricing & Reimbursement

Q5101 Private Payer Reimbursement
$0.66 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Filgrastim Biosimilar Information:

ZARXIO Approval Date: March 6, 2015

Product Name HCPCS Code Active Ingredient BLA Type
Neupogen J1442 Filgrastim 351(a) Originator Product
Zarxio Q5101 Filgrastim 351(k) Biosimilar
Nivestym Q5110 Filgrastim 351(k) Biosimilar
Releuko Q5125 Filgrastim 351(k) Biosimilar
Nypozi Q5148 Filgrastim 351(k) Biosimilar
Filkri Q5172 Filgrastim 351(k) Biosimilar

ZARXIO Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 17.19%
Avg. Days to File 9.9days
Avg. Days to Pay 22.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore Q5101 claims analytics on FocalPoint →
OnPoint Oncology

ZARXIO CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Zarxio (Q5101) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ZARXIO Medically Unlikely Edits (MUE)

The most billing units of Q5101 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mcg.

Practitioner Office & Hospital Outpatient
1,500 units / day
= 1,500 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

ZARXIO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute myeloid leukemia Autologous peripheral blood progenitor cell collection and therapy Cancer receiving myelosuppressive chemotherapy Cancer undergoing bone marrow transplantation Hematopoietic syndrome of acute radiation syndrome Severe chronic neutropenia
Drug Class
Granulocyte Colony-Stimulating Factor [CS]Increased Myeloid Cell Production [PE]Leukocyte Growth Factor [EPC]

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Frequently Asked Questions

Is there an available Zarxio billing and coding guide?
Billing and coding information for ZARXIO can be found through Sandoz. Visit Here →
Are there any available Zarxio patient assistance programs?
ZARXIO patient assistance information can be found through Sandoz. Visit Here →
Where can I find Zarxio prescribing information?
ZARXIO prescribing information can be found at the link below: Visit Here →
Where can I find Zarxio side effect information?
Information regarding ZARXIO's side effects can be found at MedlinePlus Visit Here →
Does billing ZARXIO require JZ/JW wastage modifiers?
CMS has identified ZARXIO(Q5101) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to ZARXIO.

J1442NEUPOGENInjection, filgrastim (g-csf), excludes biosimilars, 1 microgramAmgenAdded January 1, 2014Q5172FilkriInjection, filgrastim-laha (filkri), biosimilar, 1 microgramAccordAdded October 1, 2026Q5125RELUKOInjection, filgrastim-ayow, biosimilar, (releuko), 1 microgramAmneal BiosciencesAdded October 1, 2022Q5148NypoziInjection, filgrastim-txid (nypozi), biosimilar, 1 microgramCiplaAdded April 1, 2025Q5110NIVESTYMInjection, filgrastim-aafi, biosimilar, (nivestym), 1 microgramPfizerAdded October 1, 2018J1447GRANIXInjection, tbo-filgrastim, 1 microgramTevaAdded January 1, 2016J2820LEUKINEInjection, sargramostim (gm-csf), 50 mcgPartner Therapeutics, IncAdded January 1, 1982J0614GRAFAPEXInjection, treosulfan, 50 mgMedexus PharmaAdded October 1, 2025J1449ROLVEDONInjection, eflapegrastim-xnst, 0.1 mgAssertio PharmaceuticalsAdded April 1, 2023J2506NEULASTAInjection, pegfilgrastim, excludes biosimilar, 0.5 mgAmgenAdded January 1, 2022