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Updated July 1st, 2026

NIVESTYM Q Code: Q5110

Injection, filgrastim-aafi, biosimilar, (nivestym), 1 microgram

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Q4 2026 Medicare Payment Limit for Q5110, effective October 1, 2026: $0.329 per HCPCS billing unit, up 2.2% from $0.322. From CMS's final file.

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Medicare Payment Limit ?
$0.322
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$0.322
/ HCPCS billing unit · APC 9193
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
6
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Drug & Product Overview

HCPCS Descriptor Injection, filgrastim-aafi, biosimilar, (nivestym), 1 microgram
HCPCS Added Date October 1, 2018
Manufacturer Pfizer
Route of Administration Intravenous, Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About NIVESTYM

Nivestym is a medication aligned to the HCPCS Q Code: Q5110 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology Colony Stimulating Factor, it is administered via the intravenous or subcutaneous routes and manufactured by Pfizer.

According to CMS Drug Use Information: Filgrastim is a man-made version of a certain natural substance made by your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Filgrastim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy, chronic neutropenia, or exposure to large amounts of radiation). It is also used in certain treatment procedures (such as bone marrow/stem cell transplant). This monograph is about the following filgrastim products: filgrastim, filgrastim-aafi, filgrastim-ayow, filgrastim-laha, filgrastim-sndz, filgrastim-txid, and tbo-filgrastim.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 6 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00069-0291-01 Nivestym Pfizer Laboratories Div Pfizer Inc 300 300 MCG / 0.5 ML
00069-0291-10 Nivestym Pfizer Laboratories Div Pfizer Inc 3000 300 MCG / 0.5 ML
00069-0292-01 Nivestym Pfizer Laboratories Div Pfizer Inc 480 480 MCG / 0.8 ML
00069-0293-10 Nivestym Pfizer Laboratories Div Pfizer Inc 3000 300 MCG / 1 ML
00069-0294-10 Nivestym Pfizer Laboratories Div Pfizer Inc 4800 480 MCG / 1.6 ML
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NIVESTYM Pricing & Reimbursement

Q5110 Private Payer Reimbursement
$0.55 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Filgrastim Biosimilar Information:

NIVESTYM Approval Date: July 20, 2018

Product Name HCPCS Code Active Ingredient BLA Type
Neupogen J1442 Filgrastim 351(a) Originator Product
Zarxio Q5101 Filgrastim 351(k) Biosimilar
Nivestym Q5110 Filgrastim 351(k) Biosimilar
Releuko Q5125 Filgrastim 351(k) Biosimilar
Nypozi Q5148 Filgrastim 351(k) Biosimilar
Filkri Q5172 Filgrastim 351(k) Biosimilar

NIVESTYM Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 18.85%
Avg. Days to File 6.2days
Avg. Days to Pay 20.4days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore Q5110 claims analytics on FocalPoint →
OnPoint Oncology

NIVESTYM CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Nivestym (Q5110) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

NIVESTYM Medically Unlikely Edits (MUE)

The most billing units of Q5110 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mcg.

Practitioner Office & Hospital Outpatient
1,500 units / day
= 1,500 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

NIVESTYM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute myeloid leukemia receiving induction or consolidation chemotherapy Autologous peripheral blood progenitor cell collection and therapy Nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs Nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation Severe chronic neutropenia — congenital neutropenia Severe chronic neutropenia — idiopathic or cyclic neutropenia
Drug Class
Granulocyte Colony-Stimulating Factor [CS]Increased Myeloid Cell Production [PE]Leukocyte Growth Factor [EPC]

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Frequently Asked Questions

Is there an available Nivestym billing and coding guide?
Billing and coding information for NIVESTYM can be found through Pfizer. Visit Here →
Are there any available Nivestym patient assistance programs?
NIVESTYM patient assistance information can be found through Pfizer. Visit Here →
Where can I find Nivestym prescribing information?
NIVESTYM prescribing information can be found at the link below: Visit Here →
Where can I find Nivestym side effect information?
Information regarding NIVESTYM's side effects can be found at MedlinePlus Visit Here →
Does billing NIVESTYM require JZ/JW wastage modifiers?
CMS has identified NIVESTYM(Q5110) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to NIVESTYM.

Q5125RELUKOInjection, filgrastim-ayow, biosimilar, (releuko), 1 microgramAmneal BiosciencesAdded October 1, 2022Q5148NypoziInjection, filgrastim-txid (nypozi), biosimilar, 1 microgramCiplaAdded April 1, 2025Q5172FilkriInjection, filgrastim-laha (filkri), biosimilar, 1 microgramAccordAdded October 1, 2026J1442NEUPOGENInjection, filgrastim (g-csf), excludes biosimilars, 1 microgramAmgenAdded January 1, 2014Q5101ZARXIOInjection, filgrastim-sndz, biosimilar, (zarxio), 1 microgramSandozAdded July 1, 2015J1447GRANIXInjection, tbo-filgrastim, 1 microgramTevaAdded January 1, 2016J1449ROLVEDONInjection, eflapegrastim-xnst, 0.1 mgAssertio PharmaceuticalsAdded April 1, 2023J2506NEULASTAInjection, pegfilgrastim, excludes biosimilar, 0.5 mgAmgenAdded January 1, 2022Q5108FULPHILAInjection, pegfilgrastim-jmdb (fulphila), biosimilar, 0.5 mgBiocon Biologics IncAdded October 1, 2018Q5111UDENYCAInjection, pegfilgrastim-cbqv (udenyca), biosimilar, 0.5 mgAccordAdded January 1, 2019