Home › Drug Codes › J Codes › J2506 · NEULASTA
Updated July 1st, 2026

NEULASTA J Code: J2506

Injection, pegfilgrastim, excludes biosimilar, 0.5 mg

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Q4 2026 Medicare Payment Limit for J2506, effective October 1, 2026: $201.241 per HCPCS billing unit, up 40.5% from $143.233. From CMS's final file.

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Medicare Payment Limit ?
$143.233
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$143.233
/ HCPCS billing unit · APC 9436
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, pegfilgrastim, excludes biosimilar, 0.5 mg
HCPCS Added Date January 1, 2022
Manufacturer Amgen
Route of Administration Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection | Kit | Solution

About NEULASTA

Neulasta is a medication aligned to the HCPCS J Code: J2506 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology Colony Stimulating Factor drug administered via the subcutaneous route and manufactured by Amgen.

According to CMS Drug Use Information: Pegfilgrastim is a man-made version of a certain natural substance made by your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Pegfilgrastim is given to people whose ability to make white blood cells is reduced due to chemotherapy. Some brands may also be used to increase white blood cells after exposure to large amounts of radiation. This monograph is about the following pegfilgrastim products: pegfilgrastim, pegfilgrastim-apgf, pegfilgrastim-bmez, pegfilgrastim-cbqv, pegfilgrastim-fpgk, pegfilgrastim-jmdb, and pegfilgrastim-pbbk.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
55513-0190-01 Neulasta Amgen, Inc 12 6 MG / 0.6 ML
55513-0192-01 Neulasta Amgen, Inc 12 Kit
55513-0099-01 Neulasta Amgen, Inc 8 4 MG / 0.4 ML
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NEULASTA Pricing & Reimbursement

J2506 Private Payer Reimbursement
$126.11 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Pegfilgrastim Biosimilar Information:

NEULASTA Approval Date: January 31, 2002

Product Name HCPCS Code Active Ingredient BLA Type
Neulasta J2506 Pegfilgrastim 351(a) Originator Product
Fulphila Q5108 Pegfilgrastim 351(k) Biosimilar
Udenyca Q5111 Pegfilgrastim 351(k) Biosimilar
Ziextenzo Q5120 Pegfilgrastim 351(k) Biosimilar
Nyvepria Q5122 Pegfilgrastim 351(k) Biosimilar
Fylnetra Q5130 Pegfilgrastim 351(k) Biosimilar
Stimufend Q5127 Pegfilgrastim 351(k) Biosimilar
Armlupeg Q5169 Pegfilgrastim 351(k) Biosimilar
Ennumo N/A Pegfilgrastim 351(k) Biosimilar

NEULASTA Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 29.35%
Avg. Days to File 13.2days
Avg. Days to Pay 29.4days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2506 claims analytics on FocalPoint →
OnPoint Oncology

NEULASTA CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Neulasta (J2506) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

NEULASTA Medically Unlikely Edits (MUE)

The most billing units of J2506 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.5 mg.

Practitioner Office & Hospital Outpatient
12 units / day
= 6 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

NEULASTA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hematopoietic Subsyndrome of Acute Radiation Syndrome Patients with Cancer Receiving Myelosuppressive Chemotherapy
Drug Class
Granulocyte Colony-Stimulating Factor [CS]Increased Myeloid Cell Production [PE]Leukocyte Growth Factor [EPC]

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Frequently Asked Questions

Is there an available Neulasta billing and coding guide?
Billing and coding information for NEULASTA can be found through Amgen. Visit Here →
Are there any available Neulasta patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for NEULASTA.
Where can I find Neulasta prescribing information?
NEULASTA prescribing information can be found at the link below: Visit Here →
Where can I find Neulasta side effect information?
Information regarding NEULASTA's side effects can be found at MedlinePlus Visit Here →
Does billing NEULASTA require JZ/JW wastage modifiers?
CMS has identified NEULASTA(J2506) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to NEULASTA.

Q5130FYLNETRAInjection, pegfilgrastim-pbbk (fylnetra), biosimilar, 0.5 mgAmneal BiosciencesAdded April 1, 2023Q5108FULPHILAInjection, pegfilgrastim-jmdb (fulphila), biosimilar, 0.5 mgBiocon Biologics IncAdded October 1, 2018Q5120ZIEXTENZOInjection, pegfilgrastim-bmez (ziextenzo), biosimilar, 0.5 mgSandozAdded July 1, 2020Q5111UDENYCAInjection, pegfilgrastim-cbqv (udenyca), biosimilar, 0.5 mgAccordAdded January 1, 2019Q5127StimufendInjection, pegfilgrastim-fpgk (stimufend), biosimilar, 0.5 mgFresenius KabiAdded April 1, 2023Q5169Armlupeg PFSInjection, pegfilgrastim-unne (armlupeg), biosimilar, 0.5 mgValorum BiologicsAdded July 1, 2026Q5122NYVEPRIAInjection, pegfilgrastim-apgf (nyvepria), biosimilar, 0.5 mgPfizerAdded January 1, 2021J1442NEUPOGENInjection, filgrastim (g-csf), excludes biosimilars, 1 microgramAmgenAdded January 1, 2014J1447GRANIXInjection, tbo-filgrastim, 1 microgramTevaAdded January 1, 2016J1449ROLVEDONInjection, eflapegrastim-xnst, 0.1 mgAssertio PharmaceuticalsAdded April 1, 2023