DOXYCYCLINE HYCLATE J Code: J1271

Drug & Product Overview

HCPCS Descriptor Injection, doxycycline hyclate, 1 mg

HCPCS Added Date April 1, 2025

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Powder, For Solution | Injection, Powder, Lyophilized, For Solution | Powder, For Solution

About DOXYCYCLINE HYCLATE

Doxycycline Hyclate is a medication aligned to the HCPCS J Code: J1271 for billing, pricing, and reimbursement purposes in the United States. Classified under Antibiotic, it is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Doxycycline is used to treat a wide variety of bacterial infections. This medication is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 24 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9381-10	Doxycycline	Hikma Pharmaceuticals USA Inc.	1000	100 MG
42023-0244-10	Doxycycline	Par Health USA, LLC	1000	100 MG / 10 ML
43598-0086-58	Doxycycline Doxycycline	Dr. Reddy's Laboratories, Inc.	1000	100 MG / 10 ML
63323-0130-11	Doxy 100	Fresenius Kabi USA, LLC	1000	100 MG / 10 ML
66794-0237-41	Doxycycline	Piramal Critical Care Inc	1000	100 MG / 10 ML
•••••-••••-•• Log in to view	DOXYCYCLINE HYCLATE
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DOXYCYCLINE HYCLATE Pricing & Reimbursement

J1271 Private Payer Reimbursement

$0.10 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Doxycycline Hyclate 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J1271	Generic Code (Multiple Manufacturers)	Doxycycline Hyclate	Injection, doxycycline hyclate, 1 mg

DOXYCYCLINE HYCLATE CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

DOXYCYCLINE HYCLATE Medically Unlikely Edits (MUE)

The most billing units of J1271 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

DOXYCYCLINE HYCLATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Bacterial infections Bacterial infections (general) Bacterial infections (general) – less severe disease Bacterial infections (general) – severe/life-threatening (including anthrax, Rocky Mountain spotted fever) Bacterial infections (general) — less severe Bacterial infections (general) — less severe disease Bacterial infections (general) — severe or life-threatening Bacterial infections (general) — severe or life-threatening (e.g., anthrax, Rocky Mountain spotted fever) Bacterial infections (general) — severe or life-threatening (including anthrax, Rocky Mountain spotted fever) Bacterial infections (general) — severe/life-threatening Bacterial infections (general) — severe/life-threatening (e.g., anthrax, Rocky Mountain spotted fever) Bacterial infections (general), less severe disease Bacterial infections (general), severe or life-threatening (e.g., anthrax, Rocky Mountain spotted fever) Bacterial infections (general, less severe) Bacterial infections (less severe) Bacterial infections (severe or life-threatening, e.g., anthrax, Rocky Mountain spotted fever) Bacterial infections, less severe (pediatric) Inhalational anthrax (post-exposure) Primary and secondary syphilis Severe or life-threatening infections (e.g., anthrax, Rocky Mountain spotted fever) Syphilis (primary and secondary)

Show all 21 conditions Show fewer

Drug Class

Tetracycline-class Drug [EPC]Tetracyclines [CS]

Frequently Asked Questions

Is there a manufacturer-published DOXYCYCLINE HYCLATE billing and coding guide?

Our team has not identified a manufacturer-published billing and coding guide for DOXYCYCLINE HYCLATE.

What are the available DOXYCYCLINE HYCLATE patient assistance programs?

Our team has not identified a source of patient assitsance information for DOXYCYCLINE HYCLATE.

Where can I find DOXYCYCLINE HYCLATE prescribing information?

DOXYCYCLINE HYCLATE prescribing information can be found at the link below. Visit Here →

Where can I find DOXYCYCLINE HYCLATE side effect information?

Our team has not identified a source of side effect information for DOXYCYCLINE HYCLATE.

Does billing DOXYCYCLINE HYCLATE require JZ/JW wastage modifiers?

CMS does not include DOXYCYCLINE HYCLATE (J1271) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1271. For more information, visit the link below.

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