Home › Drug Codes › J Codes › J1558 · XEMBIFY
Updated July 1st, 2026

XEMBIFY J Code: J1558

Injection, immune globulin (xembify), 100 mg

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Q4 2026 Medicare Payment Limit for J1558, effective October 1, 2026: $15.20 per HCPCS billing unit, down 0.3% from $15.243. From CMS's final file.

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Medicare Payment Limit ?
$15.243
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$15.243
/ HCPCS billing unit · APC 9372
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Injection, immune globulin (xembify), 100 mg
HCPCS Added Date July 1, 2020
Manufacturer Grifols
Route of Administration Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Solution

About XEMBIFY

Xembify is a medication aligned to the HCPCS J Code: J1558 for billing, pricing, and reimbursement purposes in the United States. It is an Immunoglobulin drug administered via the subcutaneous route and manufactured by Grifols.

According to CMS Drug Use Information: This medication is used to boost the body's natural defense system against infection in persons with a weakened immune system (primary immune deficiency). Immune globulin contains natural substances called antibodies (a type called IgG) that come from healthy human blood (plasma). These antibodies help protect your body against infections and help you to fight an infection if you get sick. Some immune globulin products may also be used to treat a certain nerve disorder (chronic inflammatory demyelinating polyneuropathy-CIDP).

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
13533-0810-05 Xembify GRIFOLS USA, LLC 10 1000 MG / 5 ML
13533-0810-10 Xembify GRIFOLS USA, LLC 20 2000 MG / 10 ML
13533-0810-20 Xembify GRIFOLS USA, LLC 40 4000 MG / 20 ML
13533-0810-50 Xembify GRIFOLS USA, LLC 100 10000 MG / 50 ML
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XEMBIFY Pricing & Reimbursement

J1558 Private Payer Reimbursement
$15.55 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

XEMBIFY CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96369 Subcutaneous infusion for therapy or prophylaxis (specify substance or drug); initial, up to 1 hour, including pump set-up and establishment of subcutaneous infusion site(s)
96370 Subcutaneous infusion for therapy or prophylaxis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96371 Login for More Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular. Login for More
JW / JZ modifiers apply

CMS has identified Xembify (J1558) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

XEMBIFY Medically Unlikely Edits (MUE)

The most billing units of J1558 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 100 mg.

Practitioner Office & Hospital Outpatient
480 units / day
= 48,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

XEMBIFY Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Primary Humoral Immunodeficiency (PI)
Drug Class
Antigen Neutralization [MoA]Human Immunoglobulin G [EPC]Immunoglobulins [CS]Passively Acquired Immunity [PE]

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Frequently Asked Questions

Is there an available Xembify billing and coding guide?
Billing and coding information for XEMBIFY can be found through Grifols. Visit Here →
Are there any available Xembify patient assistance programs?
XEMBIFY patient assistance information can be found through Grifols. Visit Here →
Where can I find Xembify prescribing information?
XEMBIFY prescribing information can be found at the link below: Visit Here →
Where can I find Xembify side effect information?
Our team has not yet identified a source of side effects information for XEMBIFY. Please check back in a few weeks.
Does billing XEMBIFY require JZ/JW wastage modifiers?
CMS has identified XEMBIFY(J1558) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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