Home › Drug Codes › J Codes › J1556 · BIVIGAM
Updated July 1st, 2026

BIVIGAM J Code: J1556

Injection, immune globulin (bivigam), 500 mg

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Q4 2026 Medicare Payment Limit for J1556, effective October 1, 2026: $80.791 per HCPCS billing unit, down 0.6% from $81.241. From CMS's final file.

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Medicare Payment Limit ?
$81.241
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$81.241
/ HCPCS billing unit · APC 9130
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, immune globulin (bivigam), 500 mg
HCPCS Added Date January 1, 2014
Manufacturer Adma Biologics
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About BIVIGAM

Bivigam is a medication aligned to the HCPCS J Code: J1556 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunoglobulin, it is administered via the intravenous route and manufactured by Adma Biologics.

According to CMS Drug Use Information: This medication is used to strengthen the body's natural defense system (immune system) to lower the risk of infection in persons with a weakened immune system. This medication is made from healthy human blood that has a high level of certain defensive substances (antibodies), which help fight infections. It is also used to increase the blood count (platelets) in persons with a certain blood disorder (idiopathic thrombocytopenia purpura-ITP). Platelets are needed to stop bleeding and form blood clots. Some immune globulin products may also be used to treat certain types of muscle weakness problem (multifocal motor neuropathy, dermatomyositis) or a certain nerve disorder (chronic inflammatory demyelinating polyneuropathy-CIDP). Some products may also be used to prevent certain blood vessel disorders in people with Kawasaki syndrome.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
69800-6502-01 Bivigam ADMA Biologics, Inc. 10 5000 MG / 50 ML
69800-6503-01 Bivigam ADMA Biologics, Inc. 20 10000 MG / 100 ML
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BIVIGAM Pricing & Reimbursement

J1556 Private Payer Reimbursement
$82.04 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

BIVIGAM Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 8.15%
Avg. Days to File 6.8days
Avg. Days to Pay 23.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J1556 claims analytics on FocalPoint →
OnPoint Oncology

BIVIGAM CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
JW / JZ modifiers apply

CMS has identified Bivigam (J1556) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

BIVIGAM Medically Unlikely Edits (MUE)

The most billing units of J1556 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 500 mg.

Practitioner Office & Hospital Outpatient
240 units / day
= 120,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

BIVIGAM Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Primary Humoral Immunodeficiency
Drug Class
Antigen Neutralization [MoA]Human Immunoglobulin G [EPC]Immunoglobulins [CS]Passively Acquired Immunity [PE]

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Frequently Asked Questions

Is there an available Bivigam billing and coding guide?
Billing and coding information for BIVIGAM can be found through Adma Biologics. Visit Here →
Are there any available Bivigam patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for BIVIGAM.
Where can I find Bivigam prescribing information?
BIVIGAM prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Bivigam side effect information?
Our team has not yet identified a source of side effects information for BIVIGAM. Please check back in a few weeks.
Does billing BIVIGAM require JZ/JW wastage modifiers?
CMS has identified BIVIGAM(J1556) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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J1459PRIVIGENInjection, immune globulin (privigen), intravenous, non-lyophilized (e.g., liquid), 500 mgCSL BehringAdded January 1, 2009J1557GAMMAPLEXInjection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g., liquid), 500 mgBio Products LaboratoryAdded January 1, 2012J1561GAMMAKEDInjection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mgGrifolsAdded January 1, 2008J1569GAMMAGARD LIQUIDInjection, immune globulin, (gammagard liquid/gammagard liquid erc), 500 mgTakeda PharmaceuticalsAdded January 1, 2008J1576PANZYGAInjection, immune globulin (panzyga), intravenous, non-lyophilized (e.g., liquid), 500 mgOctapharmaAdded July 1, 2023J1577QivigyInjection, immune globulin (qivigy), 100 mgKedrion BiopharmaAdded July 1, 2026J1599PANZYGAInjection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mgOctapharmaAdded January 1, 2011J1460GAMASTANInjection, gamma globulin, intramuscular, 1 ccGrifolsAdded January 1, 1984J1551CutaquigInjection, immune globulin (cutaquig), 100 mgOctapharmaAdded July 1, 2022J1553YimmugoInjection, immune globulin (yimmugo), 100 mgKedrion BiopharmaAdded April 1, 2026