VPRIV J Code: J3385

Drug & Product Overview

HCPCS Descriptor Injection, velaglucerase alfa, 100 units

HCPCS Added Date January 1, 2011

Manufacturer Takeda Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About VPRIV

Vpriv is a medication aligned to the HCPCS J Code: J3385 for billing, pricing, and reimbursement purposes in the United States. It is an Enzyme Replacement Therapy drug administered via the intravenous route and manufactured by Takeda Pharmaceuticals.

According to CMS Drug Use Information: Velaglucerase alfa is used to treat a certain rare genetic problem (Gaucher disease). Velaglucerase alfa replaces a certain natural substance (an enzyme called glucocerebrosidase) that is missing in people with Gaucher disease. This medication improves blood, bone, liver, and spleen problems caused by Gaucher disease. Velaglucerase alfa does not correct the genetic problem, and treatment must be continued for life.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
54092-0701-04	Vpriv	Takeda Pharmaceuticals America, Inc.	4	10 MG / 4 ML

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VPRIV Pricing & Reimbursement

J3385 Private Payer Reimbursement

$386.32 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

VPRIV CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Vpriv (J3385) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

VPRIV Medically Unlikely Edits (MUE)

The most billing units of J3385 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 100 units.

Practitioner Office & Hospital Outpatient

80 units / day

= 8,000 units per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

VPRIV Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Type 1 Gaucher disease

Drug Class

Hydrolytic Lysosomal Glucocerebroside-specific Enzyme [EPC]

Frequently Asked Questions

Is there an available Vpriv billing and coding guide?

Billing and coding information for VPRIV can be found through Takeda. Visit Here →

Are there any available Vpriv patient assistance programs?

VPRIV patient assistance information can be found through Takeda. Visit Here →

Where can I find Vpriv prescribing information?

VPRIV prescribing information can be found at the link below: Visit Here →

Where can I find Vpriv side effect information?

Information regarding VPRIV's side effects can be found at MedlinePlus Visit Here →

Does billing VPRIV require JZ/JW wastage modifiers?

CMS has identified VPRIV(J3385) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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