Home › Drug Codes › J Codes › J3375 · VANCOMYCIN HCL
Updated July 1st, 2026

VANCOMYCIN HCL J Code: J3375

Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg

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Q4 2026 Medicare Payment Limit for J3375, effective October 1, 2026: $0.143 per HCPCS billing unit, up 0.7% from $0.142. From CMS's final file.

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Medicare Payment Limit ?
$0.142
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
23
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Drug & Product Overview

HCPCS Descriptor Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg
HCPCS Added Date July 1, 2025
Manufacturer Hikma
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Form Injection, Solution

About VANCOMYCIN HCL

Vancomycin HCL is a medication aligned to the HCPCS J Code: J3375 for billing, pricing, and reimbursement purposes in the United States. This Antibiotic medication is administered via the intravenous route and manufactured by Hikma.

According to CMS Drug Use Information: Vancomycin is used to treat serious bacterial infections. It is an antibiotic that works by stopping the growth of bacteria.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 23 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00143-9466-06 Tyzavan Hikma Pharmaceuticals USA Inc. 750 1250 MG / 250 ML
00143-9467-06 Tyzavan Hikma Pharmaceuticals USA Inc. 1050 1750 MG / 350 ML
00143-9468-12 Tyzavan Hikma Pharmaceuticals USA Inc. 900 750 MG / 150 ML
00143-9469-06 Tyzavan Hikma Pharmaceuticals USA Inc. 900 1500 MG / 300 ML
70594-0041-03 Vancomycin Xellia Pharmaceuticals USA LLC 600 500 MG / 100 ML
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VANCOMYCIN HCL Pricing & Reimbursement

J3375 Private Payer Reimbursement
$0.13 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Vancomycin Hcl 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J3373 Generic Code (Multiple Manufacturers) Vancomycin Hcl Injection, vancomycin hydrochloride, 10 mg
J3374 Generic Code (Multiple Manufacturers) Vancomycin Hcl Injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg
J3375 Generic Code (Multiple Manufacturers) Vancomycin Hcl Injection, vancomycin hydrochloride (tyzavan), not therapeutically equivalent to j3373, 10 mg
J3376 Hikma Vancomycin Hcl Injection, vancomycin hcl (hikma), not therapeutically equivalent to j3373, 10 mg

VANCOMYCIN HCL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

VANCOMYCIN HCL Medically Unlikely Edits (MUE)

The most billing units of J3375 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient
600 units / day
= 6,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

VANCOMYCIN HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Bone Infections Infective Endocarditis Lower Respiratory Tract Infections Septicemia Skin and Skin Structure Infections
Drug Class
Glycopeptide Antibacterial [EPC]Glycopeptides [CS]

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Frequently Asked Questions

Is there an available VANCOMYCIN HCL billing and coding guide?
Billing and coding information for VANCOMYCIN HCL can be found through Hikma. Visit Here →
Are there any available VANCOMYCIN HCL patient assistance programs?
Our team has not identified a source of patient assistance information for VANCOMYCIN HCL. Please reach out to us if this is a mistake.
Where can I find VANCOMYCIN HCL prescribing information?
VANCOMYCIN HCL prescribing information can be found at the link below. Visit Here →
Where can I find VANCOMYCIN HCL side effect information?
Side effect information for VANCOMYCIN HCL can be found through MedlinePlus. Visit Here →
Does billing VANCOMYCIN HCL require JZ/JW wastage modifiers?
CMS does not include VANCOMYCIN HCL (J3375) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J3375. For more information, visit the link below.

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