Home › Drug Codes › J Codes › J7525 · PROGRAF
Updated July 1st, 2026

PROGRAF J Code: J7525

Tacrolimus, parenteral, 5 mg

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Q4 2026 Medicare Payment Limit for J7525, effective October 1, 2026: $242.073 per HCPCS billing unit, down 9.7% from $268.176. From CMS's final file.

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Medicare Payment Limit ?
$268.176
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$268.176
/ HCPCS billing unit · APC 9006
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Tacrolimus, parenteral, 5 mg
HCPCS Added Date January 1, 2001
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection | Injection, Solution

About PROGRAF

Prograf is a medication aligned to the HCPCS J Code: J7525 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Tacrolimus is used with other medications to prevent rejection of a kidney, heart, liver, or lung transplant. The injection form of the medication is used when you cannot take the medication by mouth. As soon possible, your doctor will switch you to the form of this medication that is taken by mouth. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00469-3016-01 Prograf Astellas Pharma US, Inc. 10 5 MG / 1 ML
14789-0135-05 Tacrolimus Nexus Pharmaceuticals, LLC 10 5 MG / 1 ML
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PROGRAF Pricing & Reimbursement

J7525 Private Payer Reimbursement
$262.51 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

PROGRAF CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
JW / JZ modifiers apply

CMS has identified Prograf (J7525) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

PROGRAF Medically Unlikely Edits (MUE)

The most billing units of J7525 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.

Practitioner Office & Hospital Outpatient
2 units / day
= 10 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

PROGRAF Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Heart Transplant Kidney Transplant Liver Transplant Lung Transplant
Drug Class
Calcineurin Inhibitor Immunosuppressant [EPC]Calcineurin Inhibitors [MoA]

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Frequently Asked Questions

Is there an available Prograf billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for PROGRAF.
Are there any available Prograf patient assistance programs?
PROGRAF patient assistance information can be found through Astellas Pharma. Visit Here →
Where can I find Prograf prescribing information?
PROGRAF prescribing information can be found at the link below: Visit Here →
Where can I find Prograf side effect information?
Information regarding PROGRAF's side effects can be found at MedlinePlus Visit Here →
Does billing PROGRAF require JZ/JW wastage modifiers?
CMS has identified PROGRAF(J7525) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to PROGRAF.

J7507PROGRAFTacrolimus, immediate release, oral, 1 mgMultiple ManufacturersAdded January 1, 1995J7521PROGRAF GRANULESTacrolimus, granules, oral suspension, 0.1 mgAstellas PharmaAdded April 1, 2025J7503ENVARSUS XRTacrolimus, extended release, (envarsus xr), oral, 0.25 mgVeloxis PharmaceuticalsAdded January 1, 2016J7517CELLCEPTMycophenolate mofetil, oral, 250 mgMultiple ManufacturersAdded January 1, 2000J7519CELLCEPT - IVInjection, mycophenolate mofetil, 10 mgMultiple ManufacturersAdded October 1, 2023J7524Mycophenolate Mofetil OralMycophenolate mofetil, oral, 5 mgMultiple ManufacturersAdded October 1, 2026J7526Mycophenolate Mofetil IVInjection, mycophenolate mofetil, 5 mgMultiple ManufacturersAdded October 1, 2026J7528MYCOPHENOLATE MOFETIL ORALMycophenolate mofetil, for suspension, oral, 100 mgMultiple ManufacturersAdded January 1, 2026J7529Mycophenolate Mofetil Oral SuspensionMycophenolate mofetil, for suspension, oral, 5 mgMultiple ManufacturersAdded October 1, 2026J7508ASTAGRAF XLTacrolimus, extended release, (astagraf xl), oral, 0.1 mgAstellas PharmaAdded January 1, 2014