PROGRAF J Code: J7525

Drug & Product Overview

HCPCS Descriptor Tacrolimus, parenteral, 5 mg

HCPCS Added Date January 1, 2001

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Solution

About PROGRAF

Prograf is a medication aligned to the HCPCS J Code: J7525 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Tacrolimus is used with other medications to prevent rejection of a kidney, heart, liver, or lung transplant. The injection form of the medication is used when you cannot take the medication by mouth. As soon possible, your doctor will switch you to the form of this medication that is taken by mouth. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00469-3016-01	Prograf	Astellas Pharma US, Inc.	10	5 MG / 1 ML
14789-0135-05	Tacrolimus	Nexus Pharmaceuticals, LLC	10	5 MG / 1 ML

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PROGRAF Pricing & Reimbursement

J7525 Private Payer Reimbursement

$262.51 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

PROGRAF CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Prograf (J7525) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

PROGRAF Medically Unlikely Edits (MUE)

The most billing units of J7525 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.

Practitioner Office & Hospital Outpatient

2 units / day

= 10 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

PROGRAF Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Heart Transplant Kidney Transplant Liver Transplant Lung Transplant

Drug Class

Calcineurin Inhibitor Immunosuppressant [EPC]Calcineurin Inhibitors [MoA]

Frequently Asked Questions

Is there an available Prograf billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for PROGRAF.

Are there any available Prograf patient assistance programs?

PROGRAF patient assistance information can be found through Astellas Pharma. Visit Here →

Where can I find Prograf prescribing information?

PROGRAF prescribing information can be found at the link below: Visit Here →

Where can I find Prograf side effect information?

Information regarding PROGRAF's side effects can be found at MedlinePlus Visit Here →

Does billing PROGRAF require JZ/JW wastage modifiers?

CMS has identified PROGRAF(J7525) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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