Home › Drug Codes › J Codes › J7508 · ASTAGRAF XL
Updated July 1st, 2026

ASTAGRAF XL J Code: J7508

Tacrolimus, extended release, (astagraf xl), oral, 0.1 mg

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Q4 2026 Medicare Payment Limit for J7508, effective October 1, 2026: $0.604 per HCPCS billing unit, up 0.5% from $0.601. From CMS's final file.

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Medicare Payment Limit ?
$0.601
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Tacrolimus, extended release, (astagraf xl), oral, 0.1 mg
HCPCS Added Date January 1, 2014
Manufacturer Astellas Pharma
Route of Administration Oral
Generic Status Single-Source; Branded
Dosage Form Capsule, Coated, Extended Release

About ASTAGRAF XL

Astagraf XL is a medication aligned to the HCPCS J Code: J7508 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunosuppressant, it is administered via the oral route and manufactured by Astellas Pharma.

According to CMS Drug Use Information: Tacrolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00469-0647-73 Astagraf Xl Astellas Pharma US, Inc. 150 .5 MG
00469-0677-73 Astagraf Xl Astellas Pharma US, Inc. 300 1 MG
00469-0687-73 Astagraf Xl Astellas Pharma US, Inc. 1500 5 MG
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ASTAGRAF XL Pricing & Reimbursement

J7508 Private Payer Reimbursement
$0.79 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

ASTAGRAF XL Medically Unlikely Edits (MUE)

The most billing units of J7508 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
0 units / day
Not payable in this setting
Hospital Outpatient
300 units / day
= 30 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.
Not on the CMS JW / JZ list

CMS does not include Astagraf XL (J7508) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7508. Wastage billing guide →

ASTAGRAF XL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Kidney transplant rejection prophylaxis
Drug Class
Calcineurin Inhibitor Immunosuppressant [EPC]Calcineurin Inhibitors [MoA]

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Frequently Asked Questions

Is there an available Astagraf Xl billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for ASTAGRAF XL.
Are there any available Astagraf Xl patient assistance programs?
ASTAGRAF XL patient assistance information can be found through Astellas Pharma. Visit Here →
Where can I find Astagraf Xl prescribing information?
ASTAGRAF XL prescribing information can be found at the link below: Visit Here →
Where can I find Astagraf Xl side effect information?
Information regarding ASTAGRAF XL's side effects can be found at MedlinePlus Visit Here →
Does billing ASTAGRAF XL require JZ/JW wastage modifiers?
CMS does not include ASTAGRAF XL (J7508) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7508. For more information, visit the link below.

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