ASTAGRAF XL J Code: J7508

Drug & Product Overview

HCPCS Descriptor Tacrolimus, extended release, (astagraf xl), oral, 0.1 mg

HCPCS Added Date January 1, 2014

Manufacturer Astellas Pharma

Route of Administration Oral

Generic Status Single-Source; Branded

Dosage Form Capsule, Coated, Extended Release

About ASTAGRAF XL

Astagraf XL is a medication aligned to the HCPCS J Code: J7508 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunosuppressant, it is administered via the oral route and manufactured by Astellas Pharma.

According to CMS Drug Use Information: Tacrolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00469-0647-73	Astagraf Xl	Astellas Pharma US, Inc.	150	0.5 MG
00469-0677-73	Astagraf Xl	Astellas Pharma US, Inc.	300	1 MG
00469-0687-73	Astagraf Xl	Astellas Pharma US, Inc.	1500	5 MG

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ASTAGRAF XL Pricing & Reimbursement

J7508 Private Payer Reimbursement

$0.79 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

ASTAGRAF XL Medically Unlikely Edits (MUE)

The most billing units of J7508 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

0 units / day

Not payable in this setting

Hospital Outpatient

300 units / day

= 30 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Not on the CMS JW / JZ list

CMS does not include Astagraf XL (J7508) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7508. Wastage billing guide →

ASTAGRAF XL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Kidney transplant rejection prophylaxis

Drug Class

Calcineurin Inhibitor Immunosuppressant [EPC]Calcineurin Inhibitors [MoA]

Frequently Asked Questions

Is there an available Astagraf Xl billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for ASTAGRAF XL.

Are there any available Astagraf Xl patient assistance programs?

ASTAGRAF XL patient assistance information can be found through Astellas Pharma. Visit Here →

Where can I find Astagraf Xl prescribing information?

ASTAGRAF XL prescribing information can be found at the link below: Visit Here →

Where can I find Astagraf Xl side effect information?

Information regarding ASTAGRAF XL's side effects can be found at MedlinePlus Visit Here →

Does billing ASTAGRAF XL require JZ/JW wastage modifiers?

CMS does not include ASTAGRAF XL (J7508) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7508. For more information, visit the link below.

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