PROGRAF GRANULES J Code: J7521

Drug & Product Overview

HCPCS Descriptor Tacrolimus, granules, oral suspension, 0.1 mg

HCPCS Added Date April 1, 2025

Manufacturer Astellas Pharma

Route of Administration Oral

Generic Status Single-Source; Branded

Dosage Form Granule, For Suspension

About PROGRAF GRANULES

Prograf Granules is a medication aligned to the HCPCS J Code: J7521 for billing, pricing, and reimbursement purposes in the United States. This Immunosuppressant medication is administered via the oral route and manufactured by Astellas Pharma.

According to CMS Drug Use Information: Tacrolimus is used with other medications to prevent rejection of a kidney, heart, liver, or lung transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00469-1230-50	Prograf	Astellas Pharma US, Inc.	100	.2 MG
00469-1330-50	Prograf	Astellas Pharma US, Inc.	500	1 MG

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PROGRAF GRANULES Pricing & Reimbursement

J7521 Private Payer Reimbursement

$1.24 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

PROGRAF GRANULES Medically Unlikely Edits (MUE)

The most billing units of J7521 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 30 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

PROGRAF GRANULES Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Heart Transplant Kidney Transplant Liver Transplant Lung Transplant

Drug Class

Calcineurin Inhibitor Immunosuppressant [EPC]Calcineurin Inhibitors [MoA]

Frequently Asked Questions

Is there a manufacturer-published PROGRAF GRANULES billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for PROGRAF GRANULES.

What are the available PROGRAF GRANULES patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for PROGRAF GRANULES.

Where can I find PROGRAF GRANULES prescribing information?

PROGRAF GRANULES prescribing information can be found at the link below. Visit Here →

Where can I find PROGRAF GRANULES side effect information?

Side effect information for PROGRAF GRANULES can be found at the following source.

Does billing PROGRAF GRANULES require JZ/JW wastage modifiers?

CMS does not include PROGRAF GRANULES (J7521) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J7521. For more information, visit the link below.

About BuyandBill.com:

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