NEBUPENT J Code: J2545

Drug & Product Overview

HCPCS Descriptor Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg

HCPCS Added Date January 1, 1992

Manufacturer Multiple Manufacturers

Route of Administration Inhalation

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Inhalant

About NEBUPENT

Nebupent is a medication aligned to the HCPCS J Code: J2545 for billing, pricing, and reimbursement purposes in the United States. It is an Antibiotic drug administered via the inhalation route and manufactured by multiple companies.

According to CMS Drug Use Information: Pentamidine given by inhalation is used to prevent a serious lung infection (Pneumocystis pneumonia-PCP) in people with acquired immunodeficiency syndrome (AIDS). Pentamidine belongs to a class of drugs known as antiprotozoals. It works by killing the organism that causes the infection.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 4 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
13925-0522-01	Pentamidine Isethionate	Seton Pharmaceuticals	1	300 MG
39822-3030-02	Pentamidine Isethionate	XGen Pharmaceuticals DJB, Inc.	1	300 MG / 6 ML
63323-0877-15	NebuPent	Fresenius Kabi USA, LLC	1	300 MG / 6 ML
•••••-••••-•• Log in to view	NEBUPENT

Login to view 1 more NDC package View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

NEBUPENT Pricing & Reimbursement

J2545 Private Payer Reimbursement

$90.58 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

NEBUPENT CPT Administration Codes

CPT Code	Description
94640	Pressurized or nonpressurized inhalation treatment for acute airway obstruction or for sputum induction for diagnostic purposes.

Not on the CMS JW / JZ list

CMS does not include Nebupent (J2545) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2545. Wastage billing guide →

NEBUPENT Medically Unlikely Edits (MUE)

The most billing units of J2545 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 300 mg.

Practitioner Office & Hospital Outpatient

1 unit / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

NEBUPENT Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Pneumocystis jiroveci pneumonia (PJP) prevention

Drug Class

Antiprotozoal [EPC]

Frequently Asked Questions

Is there an available Nebupent billing and coding guide?

We have not yet identified a manufacturer source of Nebupent billing and coding information.

Are there any available Nebupent patient assistance programs?

Our team did not identify a source for Nebupent patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Nebupent prescribing information?

Our team is still working to identify a prescribing information source for NEBUPENT

Where can I find Nebupent side effect information?

Our team has not yet identified a source of side effects information for NEBUPENT. Please check back in a few weeks.

Does billing NEBUPENT require JZ/JW wastage modifiers?

CMS does not include NEBUPENT (J2545) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2545. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.