Home › Drug Codes › J Codes › J2516 · PENTAMIDINE ISETHIONATE

Updated July 1st, 2026

PENTAMIDINE ISETHIONATE J Code: J2516

Injection, pentamidine isethionate, 1 mg

Medicare Payment Limit ?

$0.16

/ HCPCS billing unit · Q3 2026

APC Payment Limit ?

Not published

CMS publishes none for Q3 2026

ASP ?

$•••.••

WAC · AWP ?

$•••.••

NDCs Crosswalked ?

View NDC crosswalk →

Drug & Product Overview

HCPCS Descriptor Injection, pentamidine isethionate, 1 mg

HCPCS Added Date January 1, 2026

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About PENTAMIDINE ISETHIONATE

Pentamidine Isethionate is a medication aligned to the HCPCS J Code: J2516 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Fungal, it is administered via the intramuscular or intravenous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Pentamidine given by inhalation is used to prevent a serious lung infection (Pneumocystis pneumonia-PCP) in people with acquired immunodeficiency syndrome (AIDS). Pentamidine belongs to a class of drugs known as antiprotozoals. It works by killing the organism that causes the infection.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 5 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
23155-0748-41	pentamidine isethionate	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	3000	300 MG
00121-1101-02	Pentamidine Isethionate	PAI Holdings, LLC dba PAI Pharma	3000	300 MG
•••••-••••-•• Log in to view	PENTAMIDINE ISETHIONATE
	PENTAMIDINE ISETHIONATE
	PENTAMIDINE ISETHIONATE

Login to view 3 more NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

PENTAMIDINE ISETHIONATE Pricing & Reimbursement

J2516 Private Payer Reimbursement

$0.24 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Pentamidine Isethionate 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2516	Generic Code (Multiple Manufacturers)	Pentamidine Isethionate	Injection, pentamidine isethionate, 1 mg

PENTAMIDINE ISETHIONATE CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

PENTAMIDINE ISETHIONATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Pneumonia due to Pneumocystis carinii

Drug Class

Antiprotozoal [EPC]

Frequently Asked Questions

Is there a manufacturer-published PENTAMIDINE ISETHIONATE billing and coding guide?

We have not identified a manufacturer-published source of billing and coding information for PENTAMIDINE ISETHIONATE. Please reach out to our team if you believe that this is a mistake.

Is there an available PENTAMIDINE ISETHIONATE patient assistance program?

Our team did not identify a source of patient assistance information for PENTAMIDINE ISETHIONATE. Please reach out if you believe that this is a mistake.

Where can I find PENTAMIDINE ISETHIONATE prescribing information?

We have not identified a source of prescribing information for PENTAMIDINE ISETHIONATE.

Where can I find PENTAMIDINE ISETHIONATE side effect information?

PENTAMIDINE ISETHIONATE side effect information can be found through MedlinePlus. Visit Here →

Does billing PENTAMIDINE ISETHIONATE require JZ/JW wastage modifiers?

CMS does not include PENTAMIDINE ISETHIONATE (J2516) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2516. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.

PENTAMIDINE ISETHIONATE Pricing

Q3 2026

J2516

Medicare Payment Limit per HCPCS unit

$0.16

Medicare Co-Insurance20% · per HCPCS unit $0.03

APC Payment Limit per HCPCS unit

Not published

ASP · WAC · AWP per HCPCS unit and NDC package

NDC Crosswalk

5 NDCs

23155-0748-41 · 00121-1101-02 · +3 more View full NDC crosswalk →

Brand Resources

Side Effect Information via medlineplus.gov

For manufacturers

Is PENTAMIDINE ISETHIONATE your product?

Sponsored pages give every visitor free access to the pricing, coding, and reimbursement data that normally requires a login, shared in a compliant way. Sponsors also get preferential search placement, their own resources on the page, and more.

Learn about page sponsorship