REZZAYO J Code: J0349

Drug & Product Overview

HCPCS Descriptor Injection, rezafungin, 1 mg

HCPCS Added Date October 1, 2023

Manufacturer Melinta Therapeutics

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About REZZAYO

Rezzayo is a medication aligned to the HCPCS J Code: J0349 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-Fungal drug administered via the intravenous route and manufactured by Melinta Therapeutics.

According to CMS Drug Use Information: This medication is used to treat certain fungal infections (candidemia, invasive candidiasis). Rezafungin belongs to a class of drugs known as echinocandins. It works by stopping the growth of fungi.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
70842-0240-01	Rezzayo	Melinta Therapeutics, LLC	200	200 MG

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REZZAYO Pricing & Reimbursement

J0349 Private Payer Reimbursement

$10.61 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

REZZAYO CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

REZZAYO Medically Unlikely Edits (MUE)

The most billing units of J0349 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

400 units / day

= 400 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

REZZAYO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Candidemia and invasive candidiasis

Drug Class

Echinocandin Antifungal [EPC]Lipopeptides [CS]

Frequently Asked Questions

Is there an available Rezzayo billing and coding guide?

Billing and coding information for REZZAYO can be found through MELINTA THERAPEUTICS, LLC. Visit Here →

Are there any available Rezzayo patient assistance programs?

REZZAYO patient assistance information can be found through MELINTA THERAPEUTICS, LLC. Visit Here →

Where can I find Rezzayo prescribing information?

REZZAYO prescribing information can be found at the link below: Visit Here →

Where can I find Rezzayo side effect information?

Information regarding REZZAYO's side effects can be found at MedlinePlus Visit Here →

Does billing REZZAYO require JZ/JW wastage modifiers?

CMS does not include REZZAYO (J0349) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0349. For more information, visit the link below.

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