AMPHOTERICIN B J Code: J0285

Drug & Product Overview

HCPCS Descriptor Injection, amphotericin b, 50 mg

HCPCS Added Date January 1, 1999

Manufacturer XGen Pharmaceuticals DJB, Inc

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About AMPHOTERICIN B

Amphotericin B is a medication aligned to the HCPCS J Code: J0285 for billing, pricing, and reimbursement purposes in the United States. This Anti-Fungal medication is administered via the intravenous route and manufactured by XGen Pharmaceuticals DJB, Inc.

According to CMS Drug Use Information: See also Warning section. This medication is used to treat a variety of serious, possibly fatal fungal infections. It works by stopping the growth of fungi.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
39822-1055-05	Amphotericin B	XGen Pharmaceuticals DJB, Inc.	1	50 MG / 10 ML

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AMPHOTERICIN B Pricing & Reimbursement

J0285 Private Payer Reimbursement

$43.47 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

AMPHOTERICIN B CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Amphotericin B (J0285) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0285. Wastage billing guide →

AMPHOTERICIN B Medically Unlikely Edits (MUE)

The most billing units of J0285 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg.

Practitioner Office & Hospital Outpatient

5 units / day

= 250 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

AMPHOTERICIN B Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

American mucocutaneous leishmaniasis Aspergillosis Fungal infections (aspergillosis, cryptococcosis, blastomycosis, systemic candidiasis, coccidioidomycosis, histoplasmosis, zygomycosis/mucormycosis, sporotrichosis) Rhinocerebral phycomycosis (zygomycosis/mucormycosis) Sporotrichosis

Drug Class

Lipid-based Polyene Antifungal [EPC]Polyene Antifungal [EPC]Polyenes [CS]

Frequently Asked Questions

Is there an available Amphotericin B billing and coding guide?

We have not yet identified a manufacturer source of Amphotericin B billing and coding information.

Are there any available Amphotericin B patient assistance programs?

Our team did not identify a source for Amphotericin B patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Amphotericin B prescribing information?

AMPHOTERICIN B prescribing information can be found at the link below: Visit Here →

Where can I find Amphotericin B side effect information?

Information regarding AMPHOTERICIN B's side effects can be found at MedlinePlus Visit Here →

Does billing AMPHOTERICIN B require JZ/JW wastage modifiers?

CMS does not include AMPHOTERICIN B (J0285) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0285. For more information, visit the link below.

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