NALOXONE HCL J Code: J2312
Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
Q4 2026 Medicare Payment Limit for J2312, effective October 1, 2026: $0.076 per HCPCS billing unit, up 10.1% from $0.069. From CMS's final file.
Drug & Product Overview
About NALOXONE HCL
Naloxone HCL is a medication aligned to the HCPCS J Code: J2312 for billing, pricing, and reimbursement purposes in the United States. Classified under Anti-Addiction, it is administered via the intramuscular, intravenous, parenteral, or subcutaneous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Naloxone is used for the emergency treatment of known or suspected opioid overdose. Serious opioid overdose symptoms may include unusual sleepiness, unusual difficulty waking up, or breathing problems (ranging from slow/shallow breathing to no breathing). Other symptoms of overdose may include very small "pinpoint" pupils, slow heartbeat, or low blood pressure. If someone has serious overdose symptoms but you are not sure if the symptoms are due to opioid overdose, give naloxone right away anyway, since lasting slow/shallow breathing may cause permanent damage to the brain or death. Since symptoms of opioid overdose may return after treatment, be sure to get medical help right away after giving the first dose of naloxone. Naloxone belongs to a class of drugs known as opioid antagonists. It works by blocking the effects of the opioid in the brain.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 46 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00409-1215-01 | Naloxone Hydrochloride | Hospira, Inc. | 400 | 0.4 MG / 1 ML |
| 00641-6132-25 | Naloxone Hydrochloride | Hikma Pharmaceuticals USA Inc. | 1000 | 0.4 MG / 1 ML |
| 36000-0308-10 | naloxone hydrochloride | Baxter Healthcare Corporation | 400 | 0.4 MG / 1 ML |
| 42023-0224-01 | Naloxone Hydrochloride | Par Health USA, LLC | 200 | 2 MG / 2 ML |
| 43598-0750-10 | Naloxone Hydrochloride | Dr. Reddy's Laboratories, Inc. | 2000 | 2 MG / 2 ML |
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NALOXONE HCL Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Naloxone Hydrochloride 505(b)(2) Information:
| HCPCS Code | Manufacturer | Active Ingredient | HCPCS Description |
|---|---|---|---|
| J2312 | Generic Code (Multiple Manufacturers) | Naloxone Hydrochloride | Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg |
| J2313 | Us Worldmeds | Naloxone Hydrochloride | Injection, naloxone hydrochloride (zimhi), 0.01 mg |
NALOXONE HCL CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
| 96375 Login for More | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug. Login for More |
This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →
NALOXONE HCL Medically Unlikely Edits (MUE)
The most billing units of J2312 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.01 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
NALOXONE HCL Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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