Home Drug Codes J Codes J2310 · NALOXONE HCL
Updated July 1st, 2026

NALOXONE HCL J Code: J2310

Injection, naloxone hydrochloride, per 1 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
38
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Drug & Product Overview

HCPCS Descriptor Injection, naloxone hydrochloride, per 1 mg
HCPCS Added Date January 1, 1996
Manufacturer Multiple Manufacturers
Route of Administration Intramuscular, Intravenous, Parenteral, Subcutaneous
Generic Status HCPCS Discontinued
Dosage Type Single-Dose, Multi-Dose
Dosage Form Injection | Injection, Solution | Not Available

About NALOXONE HCL

Naloxone HCL is a medication aligned to the HCPCS J Code: J2310 for billing, pricing, and reimbursement purposes in the United States. This Anti-Addiction medication is administered via the intramuscular, intravenous, parenteral, or subcutaneous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Naloxone is used for the emergency treatment of known or suspected opioid overdose. Serious opioid overdose symptoms may include unusual sleepiness, unusual difficulty waking up, or breathing problems (ranging from slow/shallow breathing to no breathing). Other symptoms of overdose may include very small "pinpoint" pupils, slow heartbeat, or low blood pressure. If someone has serious overdose symptoms but you are not sure if the symptoms are due to opioid overdose, give naloxone right away anyway, since lasting slow/shallow breathing may cause permanent damage to the brain or death. Since symptoms of opioid overdose may return after treatment, be sure to get medical help right away after giving the first dose of naloxone. Naloxone belongs to a class of drugs known as opioid antagonists. It works by blocking the effects of the opioid in the brain.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

38 NDC packages are crosswalked to J2310. Package detail is available to logged-in subscribers.

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NALOXONE HCL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Naloxone HCL (J2310) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2310. Wastage billing guide →

NALOXONE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Known or suspected opioid overdose Opioid Overdose Opioid Overdose - Known or Suspected Opioid Overdose – Known or Suspected Opioid Overdose–Known or Suspected Opioid Overdose—Known or Suspected Opioid depression (complete or partial reversal) Opioid-Induced Depression Opioid-induced Depression Opioid-induced Depression (Neonatal) Opioid-induced depression Postoperative Opioid Depression Postoperative opioid depression Septic Shock Septic shock Septic shock (adjunctive — increase blood pressure) Suspected or known acute opioid overdosage (diagnosis)
Drug Class
Opioid Antagonist [EPC]Opioid Antagonists [MoA]

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Frequently Asked Questions

Is there an available Naloxone Hcl billing and coding guide?
We have not yet identified a manufacturer source of Naloxone Hcl billing and coding information.
Are there any available Naloxone Hcl patient assistance programs?
Our team did not identify a source for Naloxone Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Naloxone Hcl prescribing information?
NALOXONE HCL prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Naloxone Hcl side effect information?
Our team has not yet identified a source of side effects information for NALOXONE HCL. Please check back in a few weeks.
Does billing NALOXONE HCL require JZ/JW wastage modifiers?
CMS does not include NALOXONE HCL (J2310) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2310. For more information, visit the link below.

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