HEPAGAM B J Code: J1571

Drug & Product Overview

HCPCS Descriptor Injection, hepatitis b immune globulin (hepagam b), intramuscular, 0.5 ml

HCPCS Added Date January 1, 2008

Manufacturer Kamada

Route of Administration Intramuscular, Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About HEPAGAM B

Hepagam B is a medication aligned to the HCPCS J Code: J1571 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunoglobulin, it is administered via the intramuscular or intravenous routes and manufactured by Kamada.

According to CMS Drug Use Information: This medication is used to prevent a certain serious virus infection (hepatitis B) in people who have been exposed to this virus under certain conditions (such as direct contact with blood or body fluids containing this virus). Certain brands of this medication may also be given after a liver transplant to prevent return of hepatitis B infection in people with previous infection. Ask your doctor or pharmacist if you have questions about your particular brand. This medication is made from healthy human blood that has high levels of certain defensive substances (antibodies) that help fight hepatitis B.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 4 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
49591-0051-51	HepaGam B	Kamada Ltd.	10	HepaGam B Intramuscula r Injection 1560… Login for More
49591-0052-51	HepaGam B	Kamada Ltd.	2	HepaGam B Intramuscula r Injection 312 … Login for More
•••••-••••-•• Log in to view	HEPAGAM B
	HEPAGAM B

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HEPAGAM B Pricing & Reimbursement

J1571 Private Payer Reimbursement

$71.53 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

HEPAGAM B CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Hepagam B (J1571) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

HEPAGAM B Medically Unlikely Edits (MUE)

The most billing units of J1571 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.5 ml.

Practitioner Office & Hospital Outpatient

20 units / day

= 10 ml per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

HEPAGAM B Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Post-exposure prophylaxis — acute exposure to HBsAg-positive blood Post-exposure prophylaxis — household exposure to person with acute HBV infection Post-exposure prophylaxis — perinatal exposure of infants born to HBsAg-positive mothers Post-exposure prophylaxis — sexual exposure to HBsAg-positive persons Prevention of Hepatitis B recurrence following liver transplantation

Drug Class

Human Immunoglobulin [EPC]Immunoglobulins [CS]Passively Acquired Immunity [PE]Virus Neutralization [MoA]Virus-specific Hyperimmune Globulins [EXT]

Frequently Asked Questions

Is there an available Hepagam B billing and coding guide?

Billing and coding information for HEPAGAM B can be found through Kamada. Visit Here →

Are there any available Hepagam B patient assistance programs?

Our team did not identify a source for Hepagam B patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Hepagam B prescribing information?

HEPAGAM B prescribing information can be found at the link below: Visit Here →

Where can I find Hepagam B side effect information?

Our team has not yet identified a source of side effects information for HEPAGAM B. Please check back in a few weeks.

Does billing HEPAGAM B require JZ/JW wastage modifiers?

CMS has identified HEPAGAM B(J1571) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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