Home › Drug Codes › CPT Codes › 90371 · HYPERHEP B
Updated July 1st, 2026

HYPERHEP B CPT Drug Code: 90371

Hepatitis B immune globulin (HBIg), human, for intramuscular use

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Q4 2026 Medicare Payment Limit for 90371, effective October 1, 2026: $138.229 per HCPCS billing unit, up 0.9% from $136.952. From CMS's final file.

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Medicare Payment Limit ?
$136.952
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$136.952
/ HCPCS billing unit · APC 1630
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
8
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Drug & Product Overview

HCPCS Descriptor Hepatitis B immune globulin (HBIg), human, for intramuscular use
Manufacturer Multiple Manufacturers
Route of Administration Intramuscular
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection | Liquid | Not Available

About HYPERHEP B

Hyperhep B is a medication aligned to the HCPCS CPT Drug Code: 90371 for billing, pricing, and reimbursement purposes in the United States. This Vaccine medication is administered via the intramuscular route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to prevent a certain serious virus infection (hepatitis B) in people who have been exposed to this virus under certain conditions (such as direct contact with blood or body fluids containing this virus). Certain brands of this medication may also be given after a liver transplant to prevent return of hepatitis B infection in people with previous infection. Ask your doctor or pharmacist if you have questions about your particular brand. This medication is made from healthy human blood that has high levels of certain defensive substances (antibodies) that help fight hepatitis B.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 8 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
13533-0636-01 Hyperhep B GRIFOLS USA, LLC 1 Hyperhep B Intramuscul ar Injection 220… Login for More
13533-0636-03 Hyperhep B GRIFOLS USA, LLC 1 Hyperhep B Intramuscul ar Injection 110… Login for More
13533-0636-05 Hyperhep B GRIFOLS USA, LLC 5 Hyperhep B Intramuscul ar Injection 110… Login for More
69800-4202-01 Nabi-Hb ADMA Biologics, Inc 1 Nabi-HB Intramuscular Solution 312 UNI… Login for More
69800-4203-01 Nabi-HB ADMA Biologics, Inc. 5 Nabi-HB Intramuscular Liquid 1560 UNIT… Login for More
•••••-••••-•• Log in to view HYPERHEP B
HYPERHEP B
HYPERHEP B
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HYPERHEP B Pricing & Reimbursement

90371 Private Payer Reimbursement
$162.73 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

HYPERHEP B CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
Not on the CMS JW / JZ list

CMS does not include Hyperhep B (90371) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90371. Wastage billing guide →

HYPERHEP B Medically Unlikely Edits (MUE)

The most billing units of 90371 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 ml.

Practitioner Office & Hospital Outpatient
10 units / day
= 10 ml per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ml Enter a dose to see how many billing units it is and whether it is under the limit.

HYPERHEP B Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Exposure to Blood Containing HBsAg Household Exposure to Persons with Acute HBV Infection Perinatal Exposure of Infants Born to HBsAg-positive Mothers Sexual Exposure to HBsAg-positive Persons Sexual Exposure to an HBsAg-positive Person
Drug Class
Human Immunoglobulin [EPC]Immunoglobulins [CS]Passively Acquired Immunity [PE]Virus Neutralization [MoA]Virus-specific Hyperimmune Globulins [EXT]

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Frequently Asked Questions

Is there an available Hyperhep B billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for HYPERHEP B.
Are there any available Hyperhep B patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for HYPERHEP B.
Where can I find Hyperhep B prescribing information?
Our team is still working to identify a prescribing information source for HYPERHEP B
Where can I find Hyperhep B side effect information?
Our team has not yet identified a source of side effects information for HYPERHEP B. Please check back in a few weeks.
Does billing HYPERHEP B require JZ/JW wastage modifiers?
CMS does not include HYPERHEP B (90371) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing 90371. For more information, visit the link below.

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Explore billing, coding, and pricing for drugs related to HYPERHEP B.

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